Title

Perio-dontal - Neuro-immune axis: Expression analysis of Vitamin D and brain-derived neurotrophic factor in periodontitis patients with neuro-psychiatric disorders

Authors

Jaideep Mahendra^1,*, Devadharshini Chandrasekar¹, C Krithika², RM Baiju³, Muskan Bedi⁴, K Karunanidhi⁵ & Yasin Begam⁶

Affiliation

¹Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India; ²Department of Oral Medicine, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India; ³Department of Periodontics, Government Dental College, Kottayam, Kerala, India; ⁴Department of General Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India; ⁵Department of Research, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India; ⁶Department of Biochemistry, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India; *Corresponding author

Email

Jaideep Mahendra - E - mail: drjaideep.perio@madch.edu.in
Devadharshini Chandrasekar - E - mail: deva.akshaya@gmail.com
C Krithika - E - mail: provc@maher.ac.in
RM Baiju - E - mail: baijurm2@gmail.com
Muskan Bedi - E - mail: bedimuskan@gmail.com
K Karunanidhi - E - mail: karunanidhi12895@gmail.com
Yasin Begam - E - mail: yasinbegam.biochemistry@madch.edu.in

Article Type

Research Article

Date

Received May 1, 2025; Revised May 31, 2025; Accepted May 31, 2025, Published May 31, 2025

Abstract

The association between periodontal health, neuropsychiatric status and metabolic indicators by assessing salivary Vitamin D and brain-derived neurotrophic factor (BDNF) levels is of interest. Eighty participants were categorized into four groups based on periodontal and neuropsychiatric status. Patients with both periodontitis and neuropsychiatric disorders showed significantly higher age, BMI, plaque index and probing depth and lower Vitamin D, BDNF levels and mental health scores (p < 0.001). No significant correlation was observed between biochemical markers and periodontal parameters. The findings suggest a potential link between periodontal inflammation and neuropsychiatric conditions, emphasizing the relevance of multidisciplinary care.

Keywords

Periodontitis, neuropsychiatric disorders, vitamin D, brain-derived neurotrophic factor (BDNF), salivary biomarkers, mental health

Citation

Mahendra et al. Bioinformation 21(5): 1016-1024 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.