Title

Efficacy of colchicine in oral submucous fibrosis: A systematic review and meta-analysis

Authors

Ajay Kumar¹, Sonam Sah², Neha Sah³, Aruna Das⁴, Monika Singh², Praveen Kumar Singh², Sneha Gupta⁵, Peeyush Shivhare^*,6, Prabhakar Kumar⁴ & Amit Kumar Bansal⁷

Affiliation

¹Department of Oral Medicine and Radiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India; ²Department of Dentistry, All India Institute of Medical Sciences, Gorakhpur, Kunraghat-273008, India; ³Department of Dentistry, MaaVindhyavasini Autonomous State Medical College, Mirzapur, Uttar Pradesh, India; ⁴Department of Oral Medicine & Radiology, Dental College Azamgarh, Azamgarh, Uttar Pradesh, India; ⁵Department of Oral and Maxillofacial Surgery, Institute of Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, India; ⁶Department of Dentistry, Baba Kinaram Autonomous State Medical College, Chandauli, Uttar Pradesh, India; ⁷Department of Oral Medicine and Radiology, Guru Nanakdev Dental College and Research Institute, Sunam, Punjab, India; *Corresponding author

Email

Ajay Kumar - E - mail: drajaysinghbhu@gmail.com
Sonam Sah - E - mail: dr.sonusah@gmail.com
Neha Sah - E - mail: dr.nehasah@gmail.com
Aruna Das - E - mail: arunadash22@gmail.com
Monika Singh - E - mail: monika1012singh@gmail.com
Praveen Kumar Singh - E - mail: georgianpraveen3223@gmail.com
Sneha Gupta - E - mail: gahens@gmail.com
Peeyush Shivhare - E - mail: drshivharepeeyush3@gmail.com
Prabhakar Kumar - E - mail: drprabha251088@gmail.com
Amit Kumar Bansal - E - mail: bansaldentalworld@gmail.com

Article Type

Review

Date

Received May 1, 2025; Revised May 31, 2025; Accepted May 31, 2025, Published May 31, 2025

Abstract

One of the potentially malignant disorders of the oral mucosa in Asian nations is known as oral submucous fibrosis (OSMF). The drug, surgical and combination therapies are some of the several OSMF treatment options. The importance of colchicine in the treatment of oral submucous fibrosis is still unclear. Therefore, it is of interest to review the efficacy of colchicine in oral submucous fibrosis in terms of improving symptoms such as burning sensation and mouth opening. Known data shows colchicine is in alleviating these symptoms in OSMF patients.

Keywords

Colchicine, oral sub-mucous fibrosis, potentially malignant disorder

Citation

Kumar et al. Bioinformation 21(5): 1087-1092 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.