Title

Assessment of peri-neural invasion in oral cancer patients using MRI: A clinical and radiologic correlation study

Authors

Diksha Koushal¹, Shaivi Sharma^2,*, Cheena Singh³, Mangala Sajjanar⁴, Prachi Nayak⁵, Swapna Munga⁶ & Arpita Saha⁷

Affiliation

¹Department of Oral Medicine and Radiology, Jaipur Dental College, Jaipur, Rajasthan, India; ²Department of Dentistry, Amaltas Medical College, Dewas, MP, India; ³Department of Oral Medicine and Radiology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India; ⁴Department of Oral Pathology, Mallareddy Institute of Dental Sciences, Suraram, Hyderabad, Telangana, India; ⁵Department of Oral Pathology, MM College of Dental Sciences and Research, MM (Deemed to be University), Mullana-133207, Haryana, India; ⁶Department of Restorative and Prosthetic Dental Sciences, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia; ⁷Intern, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Patia, Bhubaneswar-751024, Odisha, India; *Corresponding author

Email

Diksha Koushal - E - mail: dikshakoushal@gmail.com
Shaivi Sharma - E - mail: drshaivisharma@gmail.com
Cheena Singh - E - mail: cheenasngh3@gmail.com
Mangala Sajjan - E - mail: mangala.sajjanar@gmail.com
Prachi Nayak - E - mail: prachi80@mmumullana.org
Swapna Munga - E - mail: swapnamungadr@gmail.com
Arpita Saha - E - mail: arpitambrs@gmail.com

Article Type

Research Article

Date

Received May 1, 2025; Revised May 31, 2025; Accepted May 31, 2025, Published May 31, 2025

Abstract

The diagnostic concordance between MRI and histopathology for detecting perineural invasion (PNI) in Oral squamous cell carcinoma (OSCC) patients is of interest. A cross-sectional analytical study was conducted involving 140 patients with histopathologically confirmed OSCC. Demographic, clinical and MRI data were collected, focusing on the presence of PNI, which was compared with histopathological findings for diagnostic accuracy. MRI is a reliable diagnostic tool for detecting perineural invasion in OSCC, with strong agreement to histopathological findings, supporting its clinical utility in treatment planning. Further studies are warranted to validate these findings across larger populations.

Keywords

Perineural invasion, oral cancer, MRI, histopathology, clinical-radiologic correlation

Citation

Koushal et al. Bioinformation 21(5): 1118-1122 (2025)

Edited by

P Babaji

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.