Title

Periapical healing in endodontic retreatment: A comparative study of nano-hydroxyapatite with and without PRF

Authors

Shelly Singh¹, Jnana Ranjan Swain^2,*, Megha Gugnani³, Ashtha Arya⁴, Ranjita Singh Baghel⁵ & Samra Shafique⁶

Affiliation

¹Department of Dental Surgery, School of Dental Medicine, University of Colorado, USA; ²Department of Pedodontics and Preventive Dentistry, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India; ³Department of Conservative and Endodontics, Yamuna Institute of Dental Sciences and Research, Gadhauli, Yamunanagar, Haryana, India; ⁴Department of Conservative Dentistry and Endodontics, SGT Dental College, Hospital and Research Institute, SGT University, Gurugram, Haryana- 122505, India; ⁵Department of Periodontics, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India; ⁶Department of Conservative Dentistry and Endodontics, Sardar Patel Postgraduate Institute of Dental and Medical Sciences, Raibareli Rd, Utrathia, Vrindavan Colony, Lucknow, Uttar Pradesh 226025, India; *Corresponding author

Email

Shelly Singh - E-mail: drshellys76@gmail.com
Jnana Ranjan Swain - E-mail: jnanaranjanswain@soa.ac.in
Megha Gugnani - E-mail: drmeghagugnani@gmail.com
Ashtha Arya - E-mail: drashthaarya@yahoo.co.in
Ranjita Singh Baghel - E-mail: ranjitasinghbaghel@gmail.com
Samra Shafique - E-mail: drsamrashafique21@gmail.com

Article Type

Research Article

Date

Received May 31, 2025; Revised May 31, 2025; Accepted May 31, 2025, Published May 31, 2025

Abstract

The efficacy of nano-hydroxyapatite (nHA) alone and in combination with platelet-rich fibrin (PRF) in enhancing periapical bone healing following endodontic retreatment is of interest. Thirty-two patients with failed endodontic treatment in anterior teeth were divided into two groups. After retreatment, apicoectomy and root-end filling with mineral trioxide aggregate (MTA) were performed. Group 1 received nHA alone, while Group 2 received a combination of nHA and PRF in the periapical cavity. Follow-ups at 1, 3, and 6 months showed significant lesion size reduction in both groups, with faster healing in the nHA+PRF group at 1 month, but no long-term differences.

Keywords

Periapical pathosis, bone healing, nano-hydroxyapatite, Platelet-Rich Fibrin (PRF), retreatment, nano-hydroxyapatite (nHA)

Citation

Singh et al. Bioinformation 21(5): 1195-1200 (2025)

Edited by

Neelam Goyal & Shruti Dabi

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.