Title
Linking pseudo-exfoliation and serum uric acid among cataract patients
Authors
N.L. Haneela, M.C. Chaitra*, N. Apoorva & Sasankadhar Reddy
Affiliation
Department of Ophthalmology, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka, India; *Corresponding author
N.L. Haneela - E-mail: honeyhaneela@gmail.com; Phone: +91 9030339988
M.C. Chaitra - E-mail: chaitramc@sduaher.ac.in; Phone: +91
8197226641
N Apoorva - E-mail: apoorvan@sduaher.ac.in; Phone: +91 7760136484
Sasankdhar Reddy - E-mail: sasankadharreddy@gmail.com; Phone: +91
9989019209
Article Type
Research Article
Date
Received June 1, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025
Abstract
Pseudo-exfoliation syndrome (PXF), an age-related condition causing fibrillar deposits in the eye, may involve metabolic factors like uric acid. Therefore, it is of interest to compare blood uric acid levels in 80 cataract patients (over 45 years) at R.L. Jalappa Hospital, Kolar, from January to December 2024, splitting them into 40 with PXF and 40 without, excluding those with secondary PXF, other eye conditions, systemic diseases affecting uric acid, or prior eye surgery and collecting age, sex and uric acid data from medical records. No significant differences were found in mean age (70.83 years for PXF vs. 69.15 years for controls; p=0.332) or sex distribution (p=0.809). However, uric acid was higher in the PXF group (4.513 mg/dL) than controls (3.908 mg/dL; p=0.016), rising with PXF severity: 3.76 mg/dL (mild), 4.49 mg/dL (moderate) and 5.29 mg/dL (severe; p=0.001). Elevated uric acid is linked to PXF presence and severity, suggesting a role in its development, though further studies are needed to confirm clinical significance.
Keywords
Pseudo-exfoliation (PXF), serum uric acid (SUA), xanthine oxidase (XO)
Citation
Haneela et al. Bioinformation 21(6): 1328-1331 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
