Title |
P300 response among children and adolescents: Age and stimulus effects
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Authors |
Sangeeta Gupta1,*, Arun Prasad2 & Gaurav Gupta3
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Affiliation |
1Department of Physiology, All India Institute of Medical Sciences (AIIMS) Gorakhpur, Uttar Pradesh, India; 2Department of Paediatrics, All India Institute of Medical Sciences (AIIMS) Patna, Bihar, India; 3Department of General Surgery, All India Institute of Medical Sciences (AIIMS) Gorakhpur, Uttar Pradesh, India; *Corresponding author
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Sangeeta Gupta - E-mail: drsangeetag@aiimsgorakhpur.edu.in, drsangeeta77.65@rediffmail.com Arun Prasad - E-mail: drarunp@aiimspatna.org Gaurav Gupta - E-mail: drgauravg@aiimsgorakhpur.edu.in
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Article Type |
Research Article
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Date |
Received June 30, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025
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Abstract |
The association between age and P300 components and also the influence of stimulus-related variations, particularly intensity and probability in children and adolescents is of interest. P300 amplitude and latency and the effects of stimulus variation on P300 components were measured in 60 subjects in the age-group of 5-18 years and analysed with one-way ANOVA. P < 0.05 was considered as statistically significant. Mean P300 latency decreased and mean N2-P3 amplitudes increased with statistical significance (p<0.001) (one-way ANOVA) with substantially greater changes till 8-11 years of age. P300 latency varied inversely with stimulus intensity and probability while N2-P3 amplitude varied positively with stimulus intensity and adversely with change in the probability in all the age-groups (p<0.001) (one-way ANOVA). Age affects both P300 latency and amplitude in the children and adolescents in a characteristic pattern and stimulus variations affect the P300 responses relatively uniformly in different younger age groups. |
Keywords |
P300, ERP, age, target stimulus, intensity, probability, latency, amplitude, children, adolescents
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Citation |
Gupta et al. Bioinformation 21(6): 1332-1339 (2025)
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
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