Title

P300 response among children and adolescents: Age and stimulus effects

Authors

Sangeeta Gupta^1,*, Arun Prasad² & Gaurav Gupta³

Affiliation

¹Department of Physiology, All India Institute of Medical Sciences (AIIMS) Gorakhpur, Uttar Pradesh, India; ²Department of Paediatrics, All India Institute of Medical Sciences (AIIMS) Patna, Bihar, India; ³Department of General Surgery, All India Institute of Medical Sciences (AIIMS) Gorakhpur, Uttar Pradesh, India; *Corresponding author

Email

Sangeeta Gupta - E-mail: drsangeetag@aiimsgorakhpur.edu.in, drsangeeta77.65@rediffmail.com

Arun Prasad - E-mail: drarunp@aiimspatna.org

Gaurav Gupta - E-mail: drgauravg@aiimsgorakhpur.edu.in

Article Type

Research Article

Date

Received June 1, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

Abstract

The association between age and P300 components and also the influence of stimulus-related variations, particularly intensity and probability in children and adolescents is of interest. P300 amplitude and latency and the effects of stimulus variation on P300 components were measured in 60 subjects in the age-group of 5-18 years and analysed with one-way ANOVA. P < 0.05 was considered as statistically significant. Mean P300 latency decreased and mean N2-P3 amplitudes increased with statistical significance (p<0.001) (one-way ANOVA) with substantially greater changes till 8-11 years of age. P300 latency varied inversely with stimulus intensity and probability while N2-P3 amplitude varied positively with stimulus intensity and adversely with change in the probability in all the age-groups (p<0.001) (one-way ANOVA). Age affects both P300 latency and amplitude in the children and adolescents in a characteristic pattern and stimulus variations affect the P300 responses relatively uniformly in different younger age groups.

Keywords

P300, ERP, age, target stimulus, intensity, probability, latency, amplitude, children, adolescents

Citation

Gupta et al. Bioinformation 21(6): 1332-1339 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.