Title

Evaluation of salivary biomarker interleukin-6 in oral squamous cell carcinoma and its clinical correlation

Authors

Dipak Chaudhari^1,*, Shilpa Motghare², Vikas Pandey³, Gunmeek Kaur⁴, Sameer Gupta⁵, Saptadisha Rakshit⁶, Miral Mehta⁷ & Bhumika J Patel⁸

Affiliation

¹Department of General Dentistry, Smilebuilderz LLC, Lancaster, Pennsylvania, US; ²Department of Pathology, SRVS, Government Medical College, Shivpuri (Madhya Pradesh), India; ³Departmnet of Pathology, Goverment Medical College, Satna, Madhya Pradesh, India; ⁴Department of Oral and Maxillofacial Surgery, Luxmi Bai Dental College and Hospital, Patiala, Punjab, India; ⁵Department of Oral & Maxillofacial Surgery, Inderprastha Dental College and Hospital, Sahibabad , Ghaziabad , Uttar Pradesh - 201010, Ghaziabad, India; ⁶Intern batch BDS 2020, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Odisha, India; ⁷Department of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat,India; ⁸Department of Dentistry, Howard University, College of Dentistry, Washington DC, USA; *Corresponding author

Email

Dipak Chaudhari - E-mail: dipakvc100@yahoo.com
Shilpa Motghare - E-mail: shilpa.motghare@gmail.com
Vikas Pandey - E-mail: vikas.pandey09@gmail.com
Gunmeek Kaur - E-mail: gunmeekkaur@gmail.com
Sameer Gupta - E-mail: sameer.gupta83@yahoo.in
SaptadishaRakshit - E-mail: rsaptadishadsang@gmail.com
Miral Mehta - E-mail: miral9829@gmail.com
Bhumika J Patel - E-mail: bhumikapatel2687@gmail.com

Article Type

Research Article

Date

Received June 1, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

Abstract

Oral Squamous Cell Carcinoma (OSCC) is a prevalent malignancy with high morbidity. Hence, this cross-sectional study evaluated salivary interleukin-6 (IL-6) levels in 30 OSCC patients versus 30 healthy controls. IL-6 levels were significantly higher in OSCC patients and increased progressively with advancing clinical stages. A strong positive correlation was found between IL-6 levels and disease stage (r = 0.82, p < 0.001). Salivary IL-6 shows promise as a non-invasive biomarker for OSCC detection and progression monitoring.

Keywords

Oral squamous cell carcinoma, interleukin-6, salivary biomarkers, non-invasive diagnostics, cancer staging

Citation

Chaudhari et al. Bioinformation 21(6): 1497-1500 (2025)

Edited by

Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.