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Title

In vitro assessment of cytokine release from gingival fibroblasts exposed to periodontal pathogens

 

Authors

Kaushal Pati Tripathi1, Rohit Mishra1, Varsha Choubey1, Ajay Kumar2,*, Arohi Aglawe3 & Anshul Gulati1

 

Affiliation

1Department of Periodontics & Implantology, Hitkarini Dental College & Hospital, Jabalpur 482005, Madhya Pradesh, India; 2Department of Oral Medicine & Radiology, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India; 3Department of Periodontology, Mansarovar Dental College, Kolar Bhopal, Madhya Pradesh-462042, India; *Corresponding author

 

Email

Kaushal Pati Tripathi - E-mail: jeevankaushal03@gmail.com; Phone: +91 9098925613
Rohit Mishra - E-mail: drrohitmishra7@gmail.com; Phone: +91 8959199997
Varsha Choubey - E-mail: varshac3008@gmail.com; Phone: +91 9977933329
Ajay Kumar - E-mail: drajaysinghbhu@gmail.com; Phone: +91 8010778572
Arohi Aglawe - E-mail: drarohiaglawe@gmail.com; Phone: +91 7724064235
Anshul Gulati - E-mail: anshul478@gmail.com; Phone: +91 8889718889

 

Article Type

Research Article

 

Date

Received June 30, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

 

Abstract

Cytokine responses of gingival fibroblasts from healthy and inflamed tissues upon exposure to P. gingivalis lipopolysaccharide (LPS) are of interest. Samples were obtained from 20 individuals undergoing periodontal procedures. Inflamed fibroblasts showed elevated secretion of IL-6, MCP-1, IL-8, and GRO. P. gingivalis LPS induced a stronger cytokine response than controls. Thus, inflamed fibroblasts can mount a secondary inflammatory response to periodontal pathogens.

 

Keywords

Gingival fibroblasts, periopathogens, inflamed gingiva, cytokines

 

Citation

Tripathi et al. Bioinformation 21(6): 1501-1505 (2025)

 

Edited by

Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.