Title |
Impact of oral pathogens on inflammatory mediator expression in oral cells
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Authors |
Pratik Sanjay Hodar1,*, Mitesh Shah2, Yihan Fu3, Priti P Shah4, Abhishek Haldia5, Anagha Agrawal6 & Miral Mehta7
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Affiliation |
1Department of Prosthodontics & Crown and Bridge, Shri Yashwantrao Chavan Memorial Medical & Rural Development Foundation's Dental College & Hospital, Vadgaon Gupta Road, Ahmednagar - 414003, Maharashtra, India; 2Department of Pathology,Bundelkhand Medical College, Sagar, Madhya Pradesh, India; 3Department of General Dentistry, SmilebuilderzLancaster, PA United States; 4Department of Oral Medicine and Radiology, Faculty of Dental Science, Dharmsinh Desai University, Nadiad, Gujarat, India; 5Department of Pediatric and Preventive Dentistry, RUHS College of Dental Sciences, Jaipur, India; 6Department of Public Health Dentistry, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India; 7Department of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India; *Corresponding author
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Pratik Sanjay Hodar - E-mail: prthod@gmail.com; Phone: +91 78985
23645
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Article Type |
Research Article
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Date |
Received June 30, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025
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Abstract |
Oral pathogens such as P. gingivalis, F. nucleatum and A. actinomycetemcomitans significantly elevate cytokine levels in oral epithelial cells. qRT - PCR analysis showed P. gingivalis induced a 4.2-fold increase in IL-1β, 3.8-fold in TNF-α, and 3.5-fold in IL-6 after 24 hours. The other pathogens also triggered a 2.4 to 3.6-fold cytokine rise (p < 0.05). This indicates their role in initiating oral inflammation through pro-inflammatory cytokine activation. Targeted microbial therapy may offer benefits in managing such conditions. |
Keywords |
Oral pathogens, inflammatory mediators, cytokines, Porphyromonas gingivalis, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, oral keratinocytes, periodontitis
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Citation |
Hodar et al. Bioinformation 21(6): 1506-1509 (2025)
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Edited by |
Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
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