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Title

Impact of oral pathogens on inflammatory mediator expression in oral cells

 

Authors

Pratik Sanjay Hodar1,*, Mitesh Shah2, Yihan Fu3, Priti P Shah4, Abhishek Haldia5, Anagha Agrawal6 & Miral Mehta7

 

Affiliation

1Department of Prosthodontics & Crown and Bridge, Shri Yashwantrao Chavan Memorial Medical & Rural Development Foundation's Dental College & Hospital, Vadgaon Gupta Road, Ahmednagar - 414003, Maharashtra, India; 2Department of Pathology,Bundelkhand Medical College, Sagar, Madhya Pradesh, India; 3Department of General Dentistry, SmilebuilderzLancaster, PA United States; 4Department of Oral Medicine and Radiology, Faculty of Dental Science, Dharmsinh Desai University, Nadiad, Gujarat, India; 5Department of Pediatric and Preventive Dentistry, RUHS College of Dental Sciences, Jaipur, India; 6Department of Public Health Dentistry, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India; 7Department of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India; *Corresponding author

 

Email

Pratik Sanjay Hodar - E-mail: prthod@gmail.com; Phone: +91 78985 23645
Mitesh Shah - E-mail: drmiteshshah@gmail.com; Phone: +91 62641 69552
Yihan Fu - E-mail: annfu2010@gmail.com; Phone: +1 813 8811
Priti P Shah - E-mail: Pritishah.fods@ddu.ac.in; Phone: +91 97129 58214
Abhishek Haldia - E-mail: haldiya.abhishek@gmail.com; Phone: +91 9166649303
Anagha Agrawal - E-mail: dranagha19851301@gmail.com; Phone: +91 9680331461
Miral Mehta - E-mail: miral9829@gmail.com; Phone: +91 96018 00379

 

Article Type

Research Article

 

Date

Received June 30, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

 

Abstract

Oral pathogens such as P. gingivalis, F. nucleatum and A. actinomycetemcomitans significantly elevate cytokine levels in oral epithelial cells. qRT - PCR analysis showed P. gingivalis induced a 4.2-fold increase in IL-1β, 3.8-fold in TNF-α, and 3.5-fold in IL-6 after 24 hours. The other pathogens also triggered a 2.4 to 3.6-fold cytokine rise (p < 0.05). This indicates their role in initiating oral inflammation through pro-inflammatory cytokine activation. Targeted microbial therapy may offer benefits in managing such conditions.

 

Keywords

Oral pathogens, inflammatory mediators, cytokines, Porphyromonas gingivalis, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, oral keratinocytes, periodontitis

 

Citation

Hodar et al. Bioinformation 21(6): 1506-1509 (2025)

 

Edited by

Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.