Title

In vitro evaluation of mutagenic potential in common oral hygiene products

Authors

Shweta Hegde^1,*, Prashanth Shetty³, Mridula Nair², Arindam Dalal³, Pankaj Bajaj³ & Sandhya James³

Affiliation

¹Department of Oral Medicine and Radiology,Triveni institute of dental sciences, hospital and research centre, Bodri, Bilaspur-495220, Chhattisgarh, India; ²Department of Biochemistry, Triveni Institute of Dental Sciences, Hospital and Research centre, Bodri, Bilaspur -495220, Chhattisgarh, India; ³Department of Prosthodontics, crown and bridge and Implantology, Triveni Institute of Dental Sciences, Hospital and Research centre, Bodri, Bilaspur -495220, Chhattisgarh, India; *Corresponding author

Email

Shweta Hegde - E-mail: drshwetashetty@gmail.com
Prashanth Shetty - E-mail: dr.prashanths@gmail.com
Mridula Nair - E-mail: nairmridul@gmail.com
ArindamDalal - E-mail: arindamdalal346@gmail.com
Pankaj Bajaj - E-mail: pankajbajaj26@gmail.com
Sandhya James - E-mail: jamessandhya22@gmail.com

Article Type

Research Article

Date

Received June 1, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

Abstract

The mutagenic potential of five commonly used oral hygiene products using the Ames test is of interest. Fluoridated and herbal toothpastes showed no mutagenicity. Alcohol-based and chlorhexidine mouthwashes demonstrated moderate mutagenic effects, especially with metabolic activation. Hydrogen peroxide mouth rinse exhibited the highest mutagenicity without S9 activation. Thus, the need for further in vivo investigation to validate safety profiles is relevant.

Keywords

Mutagenicity, oral hygiene, ames test, mouthwash, toothpaste, in vitro assay

Citation

Hegde et al. Bioinformation 21(6): 1510-1513 (2025)

Edited by

Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.