Title |
In vitro evaluation of mutagenic potential in common oral hygiene products
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Authors |
Shweta Hegde1,*, Prashanth Shetty3, Mridula Nair2, Arindam Dalal3, Pankaj Bajaj3 & Sandhya James3
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Affiliation |
1Department of Oral Medicine and Radiology,Triveni institute of dental sciences, hospital and research centre, Bodri, Bilaspur-495220, Chhattisgarh, India; 2Department of Biochemistry, Triveni Institute of Dental Sciences, Hospital and Research centre, Bodri, Bilaspur -495220, Chhattisgarh, India; 3Department of Prosthodontics, crown and bridge and Implantology, Triveni Institute of Dental Sciences, Hospital and Research centre, Bodri, Bilaspur -495220, Chhattisgarh, India; *Corresponding author
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Shweta Hegde - E-mail: drshwetashetty@gmail.com
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Article Type |
Research Article
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Date |
Received June 30, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025
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Abstract |
The mutagenic potential of five commonly used oral hygiene products using the Ames test is of interest. Fluoridated and herbal toothpastes showed no mutagenicity. Alcohol-based and chlorhexidine mouthwashes demonstrated moderate mutagenic effects, especially with metabolic activation. Hydrogen peroxide mouth rinse exhibited the highest mutagenicity without S9 activation. Thus, the need for further in vivo investigation to validate safety profiles is relevant. |
Keywords |
Mutagenicity, oral hygiene, ames test, mouthwash, toothpaste, in vitro assay
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Citation |
Hegde et al. Bioinformation 21(6): 1510-1513 (2025)
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Edited by |
Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
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