Title
Analysis of genomic traits of oral and laryngeal cancer: A comparative study
Authors
Megha Prabhakar1,*, Meenakshi Garg1, Jakkula Kishore2, Subhankar Sutradhar3, Subhash Chandra Pankaj4, Jyotsna Seth5, Miral Mehta6 & Bhumika J Patel7
Affiliation
1Department of ENT, SRVS Medical College, Shivpuri, Madhya Pradesh, India; 2Deaprtment of General Surgery, KIMS hospital Visakhapatnam, Andhra Pradesh, India; 3Department of Public health dentistry Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, India; 4Department of Prosthodontics and Implantology, Government Dental College, Raipur, Chhattisgarh, India; 5Department of Prosthodontics, Seema Dental College and Hospital, Rishikesh, Uttarakhand, India; 6Department of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India; 7Department of Dentistry, Howard University, College of Dentistry, Washington DC, USA; *Corresponding author
Megha Prabhakar - E-mail: drmegha2009@gmail.com
Meenakshi Garg - E-mail: gargmeenakshi4@gmail.com
Jakkula Kishore - E-mail: Jakkulajk@gmail.com
Subhankar Sutradhar - E-mail: ssubhankar877@gmail.com
Subhash Chandra Pankaj - E-mail: docsubhash23@gmail.com
Jyotsna Seth - E-mail: drjyotsnaseth64@gmail.com
Miral Mehta - E-mail: miral9829@gmail.com
Bhumika J Patel - E-mail: bhumikapatel2687@gmail.com
Article Type
Research Article
Date
Received June 1, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025
Abstract
Oral and laryngeal cancers exhibit overlapping clinical features but distinct genomic profiles.In a study of 60 Head and neck squamous cell carcinomas(HNSCC) cases (30 OSCC, 30 LSCC), NGS revealed TP53 mutations in 70% of oral squamous cell carcinoma (OSCC) and 83% of laryngeal squamous cell carcinoma (LSCC). CDKN2A alterations were more common in OSCC (40%) than LSCC (20%), while PIK3CA mutations were higher in LSCC (30%). NOTCH1 mutations were more frequent in OSCC (27%) than LSCC (10%). Pathway analysis showed disruptions in p53 and PI3K-Akt, with stronger enrichment in LSCC (ES: 3.42). The results suggest site-specific tumor biology influencing therapeutic targets. Molecular profiling is crucial for precision treatment in head and neck cancers.
Keywords
Oral cancer, laryngeal cancer, genomic profiling, TP53, PI3K-akt pathway, comparative oncology, next-generation sequencing
Citation
Prabhakar et al. Bioinformation 21(6): 1530-1533 (2025)
Edited by
Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
