Title

Prediction of post-operative complications among diabetic patients undergoing major surgery using biomarkers

Authors

Jekee Patel¹, Parin Patel², Himarshi Upadhyay³, Falak Saiyed⁴, Huma Saiyad⁵ & Swarnim Rathod^6,*

Affiliation

¹Department of Surgery, GMERS Medical College and Hospital, Vadnagar, Gujarat, India; ²Department of General Surgery, Health 1 Super Specialty Hospital, Ahmedabad, Gujarat, India; ³Department of Internal Medicine, GMERS Medical College and Hospital, Vadnagar, Gujarat, India; ⁴Department of Medicine, NHL Municipal Medical College, Ahmedabad, Gujarat, India; ⁵Department of Medicine, BJ Medical College, Ahmedabad, Gujarat, India; ⁶House Officer cum Tutor, GMERS Medical College and Hospital, Vadnagar, Gujarat, India; *Corresponding author

Email

Jekee Patel - E-mail: pateljekee94@gmail.com
Parin Patel - E-mail: drparinpatel@outlook.com
Himarshi Upadhyay - E-mail: upadhyayhimarshi6@gmail.com
Falak Saiyed - E-mail: falaksaiyad18@gmail.com
Huma Saiyad - E-mail: saiyedhuma1@gmail.com
Swarnim Rathod - E-mail: rsvrnym16@gmail.com

Article Type

Research Article

Date

Received June 1, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

Abstract

Evaluation of pre-operative HbA1c, CRP, IL-6, and procalcitonin levels among 150 diabetic patients undergoing major surgery is of interest. Elevated HbA1c (>8%) and CRP were strongly associated with postoperative complications such as wound infections and prolonged ICU stay. IL-6 and procalcitonin show moderates predictive accuracy for systemic inflammation. Biomarker profiling proved useful for identifying high-risk patients. Incorporating these tests can improve surgical planning and postoperative care.

Keywords

Diabetes mellitus, HbA1c, C-reactive protein, IL-6, Procalcitonin, Postoperative complications, Biomarkers, Surgical risk assessment.

Citation

Patel et al. Bioinformation 21(6): 1543-1546 (2025)

Edited by

Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.