Title

Investigating the efficacy of non-invasive vagus nerve stimulation in treating drug-resistant epilepsy

Authors

Daleena Prathiba Madda¹, Sruthi Vempatapu^2,* & Sasikanth Kanaganuru³

Affiliation

¹Department of General Medicine, New Vara Hospital, Hyderabad, Telangana, India; ²Department of Emergency Medicine, Yashoda hospitals, Hyderabad, Telangana, India; ³Department of General Medicine, Apollo Hospitals, Hyderabad, Telangana, India; *Corresponding author

Email

Daleena Prathiba Madda - E-mail: daleenaprathiba@gmail.com
Sruthi Vempatapu - E-mail: sruthishri.ss22@gmail.com
Sasikanth Kanaganuru - E-mail: sasikanth1797@gmail.com

Article Type

Research Article

Date

Received June 30, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

Abstract

Drug-resistant epilepsy (DRE) affects approximately 30% of individuals with epilepsy who do not respond to antiepileptic drugs. This randomized controlled trial evaluated the efficacy of non-invasive vagus nerve stimulation (nVNS) in 120 DRE patients. Over 12 weeks, the intervention group showed a 45% reduction in seizures and a 30% improvement in quality of life, both statistically significant. Minor side effects included headaches and neck discomfort. nVNS appears to be a safe and effective adjunctive therapy for managing DRE.

Keywords

Non-invasive vagus nerve stimulation, drug-resistant epilepsy, seizure frequency, quality of life, neuromodulator, alternative therapy.

Citation

Madda et al. Bioinformation 21(6): 1551-1554 (2025)

Edited by

Hiroj Bagde MDS, (PhD), PGDCR, PGDHHM, PGDL, PGDM

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.