Title

Impact of sleep apnea severity on left ventricular remodelling

Authors

Vutukuri Kiranmai¹, Amoolya Rao Amaravadhi², Vaishnavi Jamched³, Kosmita Karki⁴, Navneeth Jayaprakash⁵, Angel Pratapsingh Chavan^6,* & James Joseph Rajan⁷

Affiliation

¹Department of General Medicine, Sri Devaraj Urs Medical College, Tamaka, Kolar-563103, Karnataka, India; ²Department of General Medicine, Malla Reddy Institute of Medical Sciences, Hyderabad, Telangana – 500 055, India; ³Department of General Medicine, Bhaskar Medical College, Hyderabad, Telangana-500075, India; ⁴Department of Medicine, Manipal College Of Medical Sciences, Fulbari, Pokhara - 11, Kaski 33700, Nepal; ⁵Department of Medicine, D. Y. Patil Medical College Kolhapur, Maharashtra 416005, India; ⁶Department of Public Health, Primary Health Centre, Chandori, Niphad, Nashik, Maharashtra, India; ⁷Department of Internal Medicine, Gleneagles Healthcity Hospitals, Chennai, Tamil Nadu-600100, India; *Corresponding author

Email

Vutukuri Kiranmai - E-mail: vutukurikiranmai@gmail.com; Phone: +91 9482441762
Amoolya Rao Amaravadhi - E-mail: amoolyarao99@gmail.com; Phone: +91 8328004161
Vaishnavi Jamched - E-mail: vjamched@gmail.com; Phone: +91 9100938060
Kosmita Karki - E-mail: kosmitakarki1@gmail.com; Phone: +977 9841198734
Navneeth Jayaprakash - E-mail: dr.navneethjp@gmail.com; Phone: +91 8075858146
Angel Pratapsingh Chavan - E-mail: drangelchavan@gmail.com; Phone: +91 7758805330
James Joseph Rajan - E-mail: jamesjb1998@gmail.com; Phone: +91 8838180680

Article Type

Research Article

Date

Received June 30, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

Abstract

Sleep apnea is a common but often overlooked condition strongly associated with cardiovascular dysfunction, particularly left ventricular (LV) remodeling. This longitudinal study assessed changes in LV structure and function over time across sleep apnea severity groups defined by the apnea-hypopnea index (AHI). Serial echocardiographic evaluations revealed that moderate-to-severe sleep apnea was significantly correlated with increased LV mass index, systolic and diastolic dysfunction. Greater AHI severity and lack of treatment were linked to more progressive LV impairment. These results emphasize the need for early diagnosis and management of sleep apnea to reduce its long-term cardiac impact.

Keywords

Sleep apnea, left ventricular remodeling, echocardiography, cardiovascular dysfunction, apnea-hypopnea index, systolic dysfunction, diastolic dysfunction

Citation

Kiranmai et al. Bioinformation 21(6): 1593-1596 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.