Title

Analytical study on systemic lupus erythematosus and its association with cutaneous manifestations

Authors

Nutheti Pavani¹, Himanshu Dua², Mohammed Zakiullah Shareef³, Megha Joy⁴, Trisha Hammigi⁵, Sobiya Farook^6,* & Kosmita Karki⁷

Affiliation

¹Department of Dermatology, Madras Medical College, Chennai, Tamil Nadu, India; ²Department of Pediatrics, N.K.P. Salve Institute of Medical Sciences & Research Centre and Lata Mangeshkar Hospital Nagpur, Maharashtra, India; ³Department of Internal Medicine, Satyadev Multispeciality Hospital, Anakapalle Andhra Pradesh 531001; ⁴Department of General Medicine, Queen Elizabeth The Queen Mother Hospital (QEQM), Margate, Kent CT9 4AN, UK; ⁵Department of Obstetrics and Gynaecology, Madras Medical College, Chennai, Tamil Nadu, India; ⁶Department of Medicine, East Lancashire Hospital NHS Trust, Royal Blackburn Hospital, Blackburn BB2 3HH, UK; ⁷Department of Medicine, Nepal Manipal College of Medical Science, Fulbari, Pokhara - 11 , Kaski 33700, Nepal; *Corresponding author

Email

Nutheti Pavani - E-mail: pavupavani54@gmail.com
Himanshu Dua - E-mail: dr_himanshupaeds@yahoo.com
Mohammed Zakiullah Shareef - E-mail: mohammedzaki0904@gmail.com
Megha Joy - E-mail: megha.joy@nhs.net
Trisha Hammigi - E-mail: trishahammigikv1hubli@gmail.com
Sobiya Farook - E-mail: draobiyafarook@gmail.com
Kosmita Karki - E-mail: kosmitakarki1@gmail.com

Article Type

Research Article

Date

Received June 30, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

Abstract

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune illness with cutaneous involvement being the most frequent of its clinical presentations. Therefore, it is of interest to determine the prevalence and patterns of cutaneous manifestations among SLE patients and their relationship with disease activity. Data comparison of 120 SLE patients was done based on demographic profile, nature of the cutaneous lesions and association with disease activity indices like the SLE disease activity index (SLEDAI). It was found that 75% of the patients presented with cutaneous involvement, of which malar rash was the most frequent manifestation, followed by discoid lesions and photosensitivity. Higher SLEDAI scores were significantly associated with more severe cutaneous symptoms (p < 0.01). The findings underscore the importance of early recognition and treatment of skin lesions for optimal disease outcome in SLE patients.

Keywords

Systemic lupus erythematosus (SLE), cutaneous manifestations, disease activity, malar rash, SLE Disease Activity Index (SLEDAI)

Citation

Pavani et al. Bioinformation 21(6): 1627-1630 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.