Title
Prospective cohort study on vitamin D deficiency and its association with multiple sclerosis relapses
Authors
Lokesh Kumar Gurram1, Rohan Hassan Chandrashekara2, Ashok Nimmakanty Ramadas3, Sushmitha Rameshbabu3, Harinishri Thambi4, Sarita Sunil Chammanam5,* & Karrar Shaaban Imran6
Affiliation
1Department of Internal Medicine, University Hospital of Wales (UHW), Heath Park Way, Cardiff, CF14 4XW, UK; 2Department of Internal Medicine, Akash Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka 562110, India; 3Department of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India; 4Department of Surgery, Madras Medical College, Chennai, Tamil Nadu, India; 5Department of General Medicine, JSS Academy of Higher Education and Research, Mysuru – 570 015, Karnataka, India; 6Department of Medicine, University of Warith Al-Anbiyaa, Karbala Governorate, Iraq; *Corresponding author
Lokesh Kumar Gurram - E-mail: lokeshkumargurram96@gmail.com
Rohan Hassan Chandrashekara - E-mail: rohanhc90@gmail.com
Ashok Nimmakanty Ramadas - E-mail: nr_ashok@ymail.com
Sushmitha Rameshbabu - E-mail: sushmithababu999@gmail.com
Harinishri Thambi - E-mail: hariesbala@gmail.com
Sarita Sunil Chammanam - E-mail: sarita.chammanam@gmail.com
Karrar Shaaban Imran - E-mail: karrar.shaa@gmail.com
Article Type
Research Article
Date
Received June 1, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025
Abstract
Vitamin D deficiency has been related to the pathogenesis and clinical course of multiple sclerosis (MS), especially with relapse frequency. Hence, a prospective cohort study explored the relationship between serum vitamin D level and MS relapses in 120 patients in a two-year follow-up. Baseline and follow-up serum 25-hydroxyvitamin D were measured and relapse events registered and examined. The result indicated a strong negative correlation between the frequency of relapse and vitamin D (p < 0.01), such that patients with low levels of vitamin (<20 ng/mL) had higher frequencies of relapse.
Keywords
Vitamin D deficiency, multiple sclerosis, ms relapses, serum 25-hydroxyvitamin d, autoimmune disease, relapse management
Citation
Gurram et al. Bioinformation 21(6): 1639-1642 (2025)
Edited by
A Prashanth
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
