Title

Enrichment effect on motor behaviour in MPTP mice

Authors

S Geetha* & M. S Vinutha Shankar

Affiliation

Department of Physiology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India; *Corresponding author

Email

S Geetha - E-mail: geetha@sduaher.ac.in; Phone: +91 9964015609
M.S Vinutha Shankar - E-mail: vinutha@sduaher.ac.in; Phone: +91 9845065374
 

Article Type

Research Article

Date

Received June 1, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor deficits due to dopaminergic neuron loss. Neuro-protective effects of enriched environment have been well established. Therefore, it is of interest to examine the effects of enriched housing in a 1-methyl-4- phenyl 1, 2, 3, 6-tetrahydropyridine (MPTP)-induced mouse model of PD. Thirty-two male C57BL/6 mice were divided into standard and enriched housing groups, with MPTP or saline treatment. MPTP mice in standard housing showed impaired motor function, whereas MPTP mice in enriched housing did not show decline in motor function, demonstrating the beneficial effects of environmental enrichment in MPTP mice.
 

Keywords

Parkinson's disease (PD), enriched environment, 1-methyl-4- phenyl 1, 2, 3, 6-tetrahydropyridine (MPTP) mice

Citation

Geetha & Shankar, Bioinformation 21(6): 1672-1676 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.