Title |
Enrichment effect on motor behaviour in MPTP mice
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Authors |
S Geetha* & M. S Vinutha Shankar
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Affiliation |
Department of Physiology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India; *Corresponding author
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S Geetha - E-mail: geetha@sduaher.ac.in;
Phone: +91 9964015609 |
Article Type |
Research Article
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Date |
Received June 1, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025
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Abstract |
Parkinson's disease (PD) is a progressive
neurodegenerative disorder characterized by motor and non-motor
deficits due to dopaminergic neuron loss. Neuro-protective effects
of enriched environment have been well established. Therefore, it is
of interest to examine the effects of enriched housing in a
1-methyl-4- phenyl 1, 2, 3, 6-tetrahydropyridine (MPTP)-induced
mouse model of PD. Thirty-two male C57BL/6 mice were divided into
standard and enriched housing groups, with MPTP or saline treatment.
MPTP mice in standard housing showed impaired motor function,
whereas MPTP mice in enriched housing did not show decline in motor
function, demonstrating the beneficial effects of environmental
enrichment in MPTP mice. |
Keywords |
Parkinson's disease (PD), enriched environment, 1-methyl-4- phenyl 1, 2, 3, 6-tetrahydropyridine (MPTP) mice
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Citation |
Geetha & Shankar, Bioinformation 21(6): 1672-1676 (2025)
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
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