Title

Neonatal umbilical cord blood bilirubin as a biomarker for hyperbilirubinemia required phototherapy

Authors

Madhav Shridharrao Kadam¹_, Mohit Garg², Seema Sutay³, Sandeep Singh Matreja^4,*, Priyadarshini Rangari⁵ & Amit Rangari⁶

Affiliation

¹Department of Biochemistry, Parbhani Medical College and RP Hospital Research Institute, Maharashtra, India; ²Department of General Medicine, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; ³Department of Forensic Science, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; ⁴Department of Pathology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; ⁵Department of Dentistry, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; ⁶Department of Microbiology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; *Corresponding author

Email

Madhav Shridharrao Kadam - E-mail: kmadhv322@gmail.com
Mohit Garg - E-mail: mohit2503@gmail.com
Seema Sutay - E-mail: seemassutay@gmail.com
Sandeep Singh Matreja - E-mail: dr.sandeepsingh88@gmail.com
Priyadarshini Rangari - E-mail: drpriyakasture@gmail.com
Amit Rangari - E-mail: dr_amit123@gmail.com
 

Article Type

Research Article

Date

Received June 1, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

Abstract

Jaundice is clinical condition characterized by transient deficiency of bilirubin conjugation, leading to neonatal hyperbilirubinemia. Therefore, it is of interest to assess cord blood bilirubin as a predictor for neonatal hyper-bilirubinemia (HB) needing phototherapy in full-term neonates. In 220 neonates with HB were assigned as cases and without HB as controls. The mean cord blood bilirubin level was 2.64±0.63 and total serum bilirubin estimated on 3rd day of life was 16.14±1.4. Umbilical cord blood bilirubin estimation is a non-invasive, economical and simple method of predicting subsequent neonatal hyper-bilirubinemia that can help clinicians for early discharge of normal neonates and follow-up in high-risk infants.

Keywords

Cord blood bilirubin, neonates, neonatal hyperbilirubinemia, phototherapy, serum total bilirubin

Citation

Kadam et al. Bioinformation 21(6): 1677-1679 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.