Title

Role of salivary MMP-9 in OSCC detection and diagnosis: A comprehensive clinical assessment

Authors

Pranav Manek¹, Vijayta Singh², Gajendra Singh Sisodia³, Indu Tomar^4,*, Dax Abraham⁵ & Parul Agarwal⁶

Affiliation

¹Department of Oral Medicine and Radiology, Pacific Dental College and Research Centre, Udaipur, Rajasthan, India; ²Department of Pathology, Maharaja Suhel Dev Autonomous State Medical College & Mahrishi Balark Hospitals, Bahraich, Uttar Pradesh, India; ³Department of Community Medicine, Pacific Medical College & Hospital, Udaipur, Rajasthan, India; ⁴Department of Biochemistry, Research Scholar (PhD), Department of Biosciences, Manipal University, Jaipur, Rajasthan, India;  ⁵Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, School of Dental Sciences, Manav Rachna International Institute of Research And Studies, Faridabad, Haryana, India; ⁶Department of  Oral Medicine and Dental Radiology, K D Dental College and hospital, Mathura, Uttar Pradesh, India; *Corresponding author

Email

Pranav Manek - E-mail: drpranavmanek92@gmail.com
Vijayta Singh - E-mail: vijaytasingh912@gmail.com
Gajendra Singh Sisodia - E-mail: drgssisodia@gmail.com
Indu Tomar - E-mail: indootomar@gmail.com
Dax Abraham - E-mail: daxabraham.sds@mrei.ac.in
Parul Agarwal - E-mail: agrawaldr1407@gmail.com
 

Article Type

Research Article

Date

Received June 1, 2025; Revised June 30, 2025; Accepted June 30, 2025, Published June 30, 2025

Abstract

An Enzyme-Linked Immunosorbent Assay (ELISA) to measure the salivary Matrix metalloproteinase-9 (MMP-9) levels among squamous cell carcinoma patients was used. Thirty of the sixty participants in the research had a verified diagnosis of oral SCC, whereas the remaining twenty were healthy controls. Salivary MMP-9 levels were extracted by centrifugation and measured using ELISA. The results were compared between oral SCC patients and controls. Participants with oral squamous cell carcinoma had considerably greater mean salivary MMP-9 levels than healthy subjects (p<0.05). Thus, individuals with oral squamous cell carcinoma have average salivary MMP-9 levels, and those with poorly differentiated oral squamous cell carcinoma have even higher levels.

Keywords

Matrix metalloproteinase, MMP-9, Oral squamous cell carcinoma, salivary biomarker, saliva

Citation

Manek et al. Bioinformation 21(6): 1680-1682 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.