Title
Analysis of lipoprotein SPD_0792 from Streptococcus pneumoniae as a potential vaccine candidate
Authors
Shabnam Shabnam, Rasanpreet Kaur & Devinder Sehgal*
Affiliation
Molecular Immunology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India; *Corresponding author
Shabnam Shabnam - E-mail: shabnam2019@nii.ac.in
Rasanpreet Kaur - E-mail: rasanpreet20@gmail.com
Devinder Sehgal - E-mail: devinder@nii.ac.in
Article Type
Research Article
Date
Received July 1, 2025; Revised July 31, 2025; Accepted July 31, 2025, Published July 31, 2025
Abstract
Streptococcus pneumoniae remains a major global health threat, especially in young children and the elderly. Although vaccines are available, polysaccharide-based (serotype-specific) formulations are limited by high costs and rising serotype replacement. As a result, there is growing interest in developing a broadly protective, protein-based vaccine. Therefore, it is of interest to investigate SPD_0792, a putative lipoprotein, as a potential vaccine candidate. Sequence analyses revealed high conservation and surface localization. The presence of multiple B-cell and helper T-cell epitopes in SDP_0792 were identified. Structural modelling and refinement using the GalaxyRefine server confirmed a stable fold comprising of 38.9% α-helices. SPD_0792 was successfully cloned, expressed and partially purified. These findings support the potential of SPD_0792 as a novel, serotype-independent antigen for next-generation pneumococcal vaccines.
Keywords
Streptococcus pneumoniae; pneumococcal protein vaccine; lipoprotein; SPD_0792
Citation
Shabnam et al. Bioinformation 21(7): 1784-1790 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
