Title
Assessment of WOMAC index for knee osteoarthritis and its association with serum vitamin - D and serum cytokine profile
Authors
Deepak Kumar, Mithilesh Kannaujiya*, Shailendra Singh, Sanjeev Kumar, Shah Waliullah, Sujeet Kumar Chaudhary & Ashish Kumar
Affiliation
Department of Orthopaedic Surgery, King George's Medical University, Lucknow, India; *Corresponding author
Deepak Kumar - E-mail: drdeepakkumarkgmc@gmail.com
Mithilesh Kannaujiya - E-mail: mithileshkannaujiya66@gmail.com
Shailendra Singh - E-mail: shailendra81mamc@gmail.com
Sanjeev Kumar - E-mail: sanjeevkumar98@gmail.com
Shah Waliullah - E-mail: shahwali2008@gmail.com
Sujeet Kumar Chaudhary - E-mail: skchaudhary404@gmail.com
Ashish Kumar - E-mail: drashish_kumar@Indiatimes.com
Article Type
Research Article
Date
Received July 1, 2025; Revised July 31, 2025; Accepted July 31, 2025, Published July 31, 2025
Abstract
Vitamin D has immuno-modulatory and potential cartilage-regenerative effects. Therefore, it is of interest to evaluate the association between serum vitamin D levels, pro-inflammatory cytokines (IL-6, TNF-α), and functional status in patients with knee osteoarthritis (OA). In this cross-sectional analysis of 84 patients with bilateral knee OA, serum vitamin D, IL-6, TNF-α levels and WOMAC scores were recorded. Patients with vitamin D deficiency exhibited significantly higher IL-6 and TNF-α levels and worse WOMAC scores. Data shows that vitamin D deficiency is associated with increased inflammation and poorer functional outcomes in knee OA.
Keywords
Vitamin D, osteoarthritis, IL-6, TNF-α, WOMAC, inflammation, cytokines
Citation
Kumar et al. Bioinformation 21(7): 1791-1795 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
