Title
In vitro skin anti-aging potential evaluation of methanolic extract of aerial parts from Acalypha indica Linn
Authors
Rajashree Sriram* & G Prakash Yoganandam
Affiliation
Department of Pharmacognosy, Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution), Affiliated to Pondicherry University, Puducherry, India; *Corresponding author
Rajashree Sriram - E-mail: rajashreeharish77@gmail.com
G Prakash Yoganandam - E-mail: prakashyoganandam@mtpgrihs.ac.in
Article Type
Research Article
Date
Received July 1, 2025; Revised July 31, 2025; Accepted July 31, 2025, Published July 31, 2025
Abstract
The methanolic extract of aerial parts from Acalypha indica (MAIE) as potential candidates for skin aging treatment is of interest. The skin antiaging property was evaluated by its antioxidant and extracellular matrix degrading enzyme-inhibiting activity. The study reported the highest total phenolic content and total flavonoid content with notable antioxidant activity (ABTS and DPPH assay) at the concentration of 1, 2 and 5 μg/ml. The inhibitory potential of MAIE against Elastase (IC50 = 21.79 ± 0.01μg/ml) and MMP-1 (36.29 ± 0.01μg/ml), the key enzymes linked to acceleration of the aging process explicit enzyme inhibition. In vitro studies with L929 cells demonstrated that MAIE was noncytotoxic up to of 5 μg/mL, significantly reduced cell viability of irradiated cell by 48.33%, indicating its potent photoprotective capacity and exhibited effective Collagen biosynthesis by Sirius Red method. MAIE can be further developed as a natural skin antiaging agent in the cosmetics, cosmeceutical and pharmaceutical industries.
Keywords
Skin aging, treatment, aerial parts, MAIE, collagen, biosynthesis
Citation
Sriram & Yoganandam, Bioinformation 21(7): 1796-1803 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
