Title |
Seroprevalence of TTIs and its association with ABO and Rh blood groups among blood donors
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Authors |
Jyoti Kala Bharati*, Nouratan Singh, Shweta Chaudhary, Aaditya Shivhare, Arvind Kumar Singh & Yatendra Mohan
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Affiliation |
Department of Transfusion Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh-206130, India; *Corresponding author
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Jyoti Kala Bharati - E-mail: jyotikalabharati@gmail.com, jyoti.kala@upums.ac.in
Aaditya Shivhare - E-mail: aaditya.shiv@upums.ac.in
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Article Type |
Research Article
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Date |
Received July 1, 2025; Revised July 31, 2025; Accepted July 31, 2025, Published July 31, 2025
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Abstract |
Transfusion-transmitted infections (TTIs) such as HIV, HBV, HCV, syphilis, and malaria pose significant risks to blood safety. Therefore, it is of interest to assess the seroprevalence of TTIs and their association with ABO/Rh blood groups among 30,335 blood donors. Data from 30,335 donations, with 1,843 reactive units, were analyzed demographically. Overall TTI seroprevalence was 6.08%. O Negative showed the highest reactive rate (9.41%, OR=1.62, 95% CI: 1.14-2.30), followed by B Positive (7.06%, OR=1.26, 95% CI: 1.14-1.39). AB Positive had the lowest rate (4.28%, OR=0.66, 95% CI: 0.56-0.78). A significant association was confirmed (χ2=53.9, df=7, p<0.0001). O Negative and B Positive blood groups are strongly associated with higher TTI seroprevalence, while AB Positive shows lower risk. Thus, targeted screening for high-risk groups could enhance blood safety. |
Keywords |
Chemiluminescent immunoassays (CLIA), Nucleic Acid Testing (NAT), Transfusion-Transmitted Infections (TTI), ABO/Rh blood groups, seroprevalence, blood donors, chi-square test
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Citation |
Bharati et al. Bioinformation 21(7): 1912-1917 (2025)
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
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