Title

In vitro characterization of drynaria in-situ gel: A novel approach to periodontal disease management

Authors

Kaushal Pati Tripathi¹, Neelam Mittal²*, Anju Gautam1, Pragati Dubey³, Aishwarya Pandey¹ & Sakshi Gupta², Ajay Kumar⁴ & Varsha Choubey⁵

Affiliation

¹Department of Periodontology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India; ²Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India; ³Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India; ⁴Unit of Oral Medicine and Radiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India; ⁵Department of Periodontics and Implantology, Hitkarini Dental College and Hospital, Jabalpur-482001, India; *Corresponding author

Email

Kaushal Pati Tripathi - E-mail: jeevankaushal03@gmail.com
Neelam Mittal - E-mail: dr.neelammittal@gmail.com
Anju Gautam - E-mail: dranjugautam@gmail.com
Pragati Dubey - E-mail: pragait@bhu.ac.in
Aishwarya Pandey - E-mail: aishwarya22.ace@gmail.com
Sakshi Gupta - E-mail: dr.sakshiblue@gmail.com
Ajay Kumar- E-mail: drajaysinghbhu@gmail.com
Varsha Choubey- E-mail: varshac3008@gmail.com

Article Type

Research Article

Date

Received July 1, 2025; Revised July 31, 2025; Accepted July 31, 2025, Published July 31, 2025

Abstract

The condition of periodontal diseases that results from oral dysbiosis-related inflammation poses crucial public health concerns. Therefore, it is of interest to assess an in-situ gel made with Drynaria rhizome extract for local drug application in periodontal care. The Drynaria in-situ gel has desirable clinical properties because its combination of Sodium Tripolyphosphate (STPP), Poloxamer 407, Acetic Acid and Chitosan produces temperature-sensitive features and viscosity stability. Studies under laboratory conditions proved both the uniformity and stability of the gel. The tested Drynaria gel emerges as a promising choice for local drug delivery in periodontal healthcare and researchers need to conduct additional clinical trials to prove its performance in real-world conditions.

Keywords

Drynaria, in-situ gel, evaluation, periodontal diseases

Citation

Tripathi et al. Bioinformation 21(7): 2006-2011 (2025)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.