Title |
In vitro characterization of drynaria in-situ gel: A novel approach to periodontal disease management
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Authors |
Kaushal Pati Tripathi1, Neelam Mittal2*, Anju Gautam1, Pragati Dubey3, Aishwarya Pandey1 & Sakshi Gupta2, Ajay Kumar4 & Varsha Choubey5
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Affiliation |
1Department of Periodontology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India; 2Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India; 3Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India; 4Unit of Oral Medicine and Radiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India; 5Department of Periodontics and Implantology, Hitkarini Dental College and Hospital, Jabalpur-482001, India; *Corresponding author
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Kaushal Pati Tripathi - E-mail: jeevankaushal03@gmail.com
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Article Type |
Research Article
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Date |
Received July 1, 2025; Revised July 31, 2025; Accepted July 31, 2025, Published July 31, 2025
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Abstract |
The condition of periodontal diseases that results from oral dysbiosis-related inflammation poses crucial public health concerns. Therefore, it is of interest to assess an in-situ gel made with Drynaria rhizome extract for local drug application in periodontal care. The Drynaria in-situ gel has desirable clinical properties because its combination of Sodium Tripolyphosphate (STPP), Poloxamer 407, Acetic Acid and Chitosan produces temperature-sensitive features and viscosity stability. Studies under laboratory conditions proved both the uniformity and stability of the gel. The tested Drynaria gel emerges as a promising choice for local drug delivery in periodontal healthcare and researchers need to conduct additional clinical trials to prove its performance in real-world conditions. |
Keywords |
Drynaria, in-situ gel, evaluation, periodontal diseases
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Citation |
Tripathi et al. Bioinformation 21(7): 2006-2011 (2025)
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Edited by |
Hiroj Bagde, PhD
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
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