Title

Assessment of cardiac autonomic dysfunction in patients with chronic kidney disease using heart rate variability

Authors

Devpriya Shukla¹, Amit Saxena¹, Anju Jha² & Raghav Gupta^3,*

Affiliation

¹Department of General Medicine, Bundelkhand Medical College, Sagar, Madhya Pradesh, India; ²Department of Physiology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India; ³Department of Dermatology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India; *Corresponding author

Email

Devpriya Shukla - E-mail: devpriyashukla27@gmail.com
Amit Saxena - E-mail: drsaxenaamit04@gmail.com
Anju Jha - E-mail: dranjujhabmc@gmail.com
Raghav Gupta - E-mail: rockingraghav04@gmail.com

Article Type

Research Article

Date

Received July 1, 2025; Revised July 31, 2025; Accepted July 31, 2025, Published July 31, 2025

Abstract

Cardiac autonomic dysfunction has been majorly linked with chronic kidney disease (CKD) and has related this condition to an increase in cardiovascular risk. This study compared heart rate variability (HRV) and baroreflex sensitivity among 120 patients with CKD and 60 healthy individuals. Patients with CKD exhibited a significant decrease in the HRV parameters and baroreflex sensitivity (p < 0.001). The more advanced the CKD stage and the worse the eGFR, the worse the autonomic dysfunction. A non-invasive measure referred to as HRV analysis can be conducted to stratify early cardiovascular risks in CKD.

Keywords

Cardiac autonomic dysfunction, chronic kidney disease, heart rate variability, baroreflex sensitivity

Citation

Shukla et al. Bioinformation 21(7): 2069-2074 (2025)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.