Title

Phenotypic detection of multidrug resistance and metallo-β-lactamase production among clinically relevant non-fermenters at a medical centre in India

Authors

Somya Sinha¹, Shireen Shailja^2,*, Namrata Kumari³ & Shailesh Kumar³

Affiliation

¹Department of Microbiology, SNMIH, Saharsa, Bihar, India; ²Department of Microbiology, Shyamlal Chandrashekhar Medical College, Khagaria, Bihar, India; ³Department of Microbiology, IGIMS, Patna, Bihar, India; *Corresponding author

Email

Somya Sinha - E-mail: drsomyasinha31@gmail.com
Shireen Shailja - E-mail: shireenlibra90@gmail.com
Namrata Kumari - E-mail: nrainari@gmail.com
Shailesh Kumar - E-mail: shaileshgar@yahoo.com

Article Type

Research Article

Date

Received July 1, 2025; Revised July 31, 2025; Accepted July 31, 2025, Published July 31, 2025

Abstract

Non-fermenting gram-negative bacilli (NFGNB) have become a new vision of serious and clinically important nosocomial infection, with a growing multidrug resistance (MDR), as well as the production of metallo-beta-lactamase (MBL), which makes their intervention in tertiary care centres difficult. This 18-month prospective research carried out in Bihar scrutinized 342 NFGNB isolates, whereby the most dominant was Pseudomonas aeruginosa. MDR was observed in 72.8 percent of isolates and it was significantly higher in people in the ICU (p < 0.001), whereas MBL was seen in 41.2 percent of strains. The highest susceptibility was shown by colistin, polymyxin B and tigecycline. Thus, the urgent need for effective antimicrobial stewardship and infection control practices is reported.

Keywords

Non-fermenting gram-negative bacilli (NFGNB), multidrug resistance (MDR), metallo-beta-lactamase (MBL), tertiary care hospital, nosocomial infections, colistin

Citation

Sinha et al. Bioinformation 21(7): 2080-2084 (2025)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.