Title

In silico analysis of hypo-upregulated genes as biomarkers in lung adenocarcinoma

Authors

Binisha Robinson¹, Luke Elizabeth Hanna² & Shanmughavel Piramanayagam^1,*

Affiliation

¹Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu, India; ²Department of Virology and biotechnology, ICMR-National Institute for Research in Tuberculosis, Chennai-600031, India; *Corresponding author

Email

Binisha Robinson - E-mail: binisharobinson@gmail.com
Luke Elizabeth Hanna - E-mail: lukeelizebath.hanna@icmr.gov.in
Shanmughavel Piramanayagam - E-mail: shanmughavel@buc.edu.in

Article Type

Research Article

Date

Received July 1, 2025; Revised July 31, 2025; Accepted July 31, 2025, Published July 31, 2025

Abstract

Lung adenocarcinoma (LUAD), the most common kind of lung cancer, is characterized by altered gene expression and DNA methylation. This study used TCGA to evaluate methylation and expression data from LUAD. Differential analysis revealed 7313 methylated genes and 250 upregulated genes. Integration identifie "Hypo-Up" genes, which are hypomethylated and elevated, indicating carcinogenic potential. Further protein-protein interaction studies will reveal important seed genes. Data shows severe epigenetic and transcriptome abnormalities in LUAD and suggest new biomarker possibilities.

Keywords

Lung adenocarcinoma, DNA methylation, gene- expression, hypo-upregulation, biomarker, multi-omics

Citation

Robinson et al. Bioinformation 21(7): 2128-2132 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.