Title
A typical presentation of AMSAN variant of guillain–barré syndrome in an elderly female with multisystem involvement: A case report
Authors
Pratap Singh Sekhon*, Manish Pendse & Neha Momale
Affiliation
Department of General Medicine, D Y Patil University, School of Medicine, Nerul, Navi Mumbai, India; *Corresponding author
Pratap Singh Sekhon - E-mail: pratapsekhon77@gmail.com; Phone: +91 8879392424
Manish Pendse - E-mail: drmanishpendse@gmail.com
Neha Momale - E-mail: nehamomale@yahoo.co.in
Article Type
Views
Date
Received July 1, 2025; Revised July 31, 2025; Accepted July 31, 2025, Published July 31, 2025
Abstract
Guillain–Barré Syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy, with the AMSAN (Acute Motor and Sensory Axonal Neuropathy) variant representing a severe subtype characterized by rapid progression and poor prognosis. This report describes a 68-year-old woman presenting with progressive quadriparesis, cranial nerve involvement, and bowel and respiratory complications, ultimately diagnosed as AMSAN based on nerve conduction studies and cerebrospinal fluid analysis. MRI and EEG findings contributed to the diagnostic complexity due to age-related degenerative and vascular changes. Despite early IVIg administration, the patient required intensive care, emphasizing the need for prompt diagnosis and multidisciplinary management. AMSAN in elderly patients demands high clinical vigilance and early neurophysiological evaluation to initiate timely immunotherapy and improve outcomes.
Keywords
Syndrome, Acute Motor and Sensory Axonal Neuropathy (AMSAN), Prognosis, Cranial Nerve, MRI, EEG, Neurophysiological
Citation
Sekhon et al. Bioinformation 21(7): 2181-2185 (2025)
Edited by
A Prashanth
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
