Title

Molecular markers in triple-negative breast cancer: A retrospective correlation study

Authors

Sudarshan Gupta¹, Purti Agrawal Saini², Vikas Pandey³ & Mitesh Shah^4,*

Affiliation

¹Department of Pathology, VKS Government Medical College, Neemuch, Madhya Pradesh, India; ²Department of Pathology, Nandkumar Singh Chouhan Government Medical College, Khandwa, Madhya Pradesh, India; ³Department of Pathology, Government Medical College, Santa, Madhya Pradesh, India; ⁴Department of Pathology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India; *Corresponding author

Email

Sudarshan Gupta - E-mail: path.sudarshan@gmail.com
Purti Agrawal Saini - E-mail: purti.agrawal@gmail.com
Vikas Pandey - E-mail: vikas.pandey09@gmail.com
Mitesh Shah - E-mail: drmiteshshah@gmail.com

Article Type

Research Article

Date

Received July 1, 2025; Revised July 31, 2025; Accepted July 31, 2025, Published July 31, 2025

Abstract

The expression and clinical correlation of molecular markers in 128 patients diagnosed with triple-negative breast cancer (TNBC). Immunohistochemistry was used to assess markers including Ki-67, p53, EGFR and CK5/6. High Ki-67 and p53 positivity were significantly associated with higher tumor grade and lymph node involvement. EGFR and CK5/6 expression correlated with basal-like features and poor differentiation. Data suggest that molecular profiling in TNBC may guide prognosis and targeted therapies.

Keywords

Triple-negative breast cancer, Ki-67, p53, EGFR, CK5/6, basal-like phenotype, molecular markers

Citation

Gupta et al. Bioinformation 21(7): 2245-2248 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.