Title

Rage gene -374T/A polymorphism in South Indian diabetic nephropathy

Authors

Ramesh Babu Murikipudi¹, S. Lakshmiprabha²*, P. Pravallika³, D. Ponnudhali¹, S.R. Rangabashyam⁴, R Rangarajan⁵

Affiliation

¹Department of Biochemistry, Vinayaka Mission's Kirupananda Variyar Medical College & Hospital, Salem, Vinayaka Misson's Research Foundation (DU), Salem, Tamilnadu, India; ²Department of Biochemistry, KMMC Medical College and Hospital, Muttom, Kanyakumari., St. Joseph University, Bengaluru, India; ³Department of Physiology, Shridevi institute of medical sciences and research hospital Tumkur, Karnataka, India; ⁴Department of General medicine, Vinayaka Mission's Kirupananda Variyar Medical College & Hospital, Salem, India; ⁵Department of Biochemistry, Government Mohan Kumaramangalam Medical College Hospital, Shevapet, Salem, India; *Corresponding author

Email

Ramesh babu Murikipudi - E-mail: ramesvims8881@gmail.com
S. Lakshmiprabha - E-mail: agathiarlakshmi@gmail.com
P. Pravallika - E-mail: ponnudhalid@gmail.com
D. Ponnudhali - E-mail: pravallikapagadala5@gmail.com
S.R. Rangabashyam - E-mail: rangabashyamsr@yahoo.in
Rangarajan - E-mail: drrangarajan@yahoo.in

Article Type

Research Article

Date

Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025

Abstract

Diabetic nephropathy (DN) is a major complication of type 2 diabetes mellitus (T2DM) and genetic variants like RAGE -374T/A may influence disease susceptibility. Therefore, it is of interest to analyze the association between RAGE -374T/A polymorphism and DN in T2DM patients from Kolar, Karnataka. Genotyping was done by PCR-RFLP and clinical parameters were compared. No significant association was found between the polymorphism and DN (p > 0.05), though DN patients showed elevated HbA1c, microalbuminuria and dyslipidemia. These findings suggest metabolic factors, rather than this specific RAGE variant, are more strongly linked to DN risk in this population.

Keywords

Rage gene, Blood parameters, glycemic index, gene polymorphism

Citation

Murikipudi et al. Bioinformation 21(8): 2288-2292 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.