Title

Daily probiotic supplementation on plaque pH and gingival health in adults: A clinical study

Authors

Pranav V Manek¹, M Alfiya², Rashmi Sinha³, Onteru Pradeep⁴*, Heena Dixit⁵, Deepak Sharma⁵ & Rahul Tiwari⁶

Affiliation

¹Department of Oral Medicine and Radiology, Pacific Dental College and Research Centre, Udaipur, Rajasthan, India, Boston University, GMS, Chobanian & Avedisian School of Medicine, Boston, MA, USA; ²Department of Public Health Dentistry, Yenepoya Dental College, Mangalore, Karnataka, India; ³Department of Dentistry, Nalanda Medical College Hospital, Agamkuan, Patna, Bihar, India; ⁴Department of Public Health Dentistry, Father Colombo Institute of Medical Sciences, Warangal, Telangana, India; ⁵Department of Medical Health Administration, Index Institute, Malwanchal University, Index City, Nemawar Road, Indore, Madhya Pradesh, India; ⁶MHA, IIHMR University, Jaipur, Rajasthan, India; *Corresponding author

Email

Pranav V Manek - E-mail: drpranavmanek92@gmail.com
M Alfiya - E-mail: dr.alfiyamds@gmail.com
Rashmi Sinha - E-mail: rashmisinha9343@gmail.com
Onteru Pradeep - E-mail: pradeep.onteru393@gmail.com
Heena Dixit - E-mail: drheenatiwari@gmail.com
Deepak Sharma - E-mail: heena16.d@gmail.com
Rahul Tiwari - E-mail: rahultiwari.j21@iihmr.in

Article Type

Research Article

Date

Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025

Abstract

Oral health is strongly influenced by the balance of the oral microbiome, with plaque pH and gingival status serving as critical indicators of dental and periodontal well-being. A randomized, controlled clinical trial was conducted involving 60 healthy adults aged 20–45 years. The probiotic group exhibited a significant increase in plaque pH (from 5.89 ± 0.12 to 6.52 ± 0.10, p < 0.001) and a marked reduction in gingival index scores (from 1.83 ± 0.18 to 0.97 ± 0.15, p < 0.001). The control group showed no significant changes. Daily probiotic intake effectively enhanced plaque pH and gingival health, supporting its role as a preventive adjunct in routine dental care.

Keywords

Probiotics, gingival index, plaque pH, oral microbiome, preventive dentistry

Citation

Manek et al. Bioinformation 21(8): 2365-2368 (2025)

Edited by

Akshaya Ojha

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.