Title
Association of inflammatory markers and hematological inflammatory indices in predicting pseudoexfoliation
Authors
C. Harshitha & M.C. Chaitra*
Affiliation
Department of Ophthalmology, Sri Devaraj Urs Medical College, R.L. Jalappa Hospital, Kolar, Karnataka, India; *Corresponding author
C. Harshitha - E-mail: harshithachandrareddy@gmail.com
M.C. Chaitra - E-mail: drchaitramc@gmail.com, chaitramc@sduaher.ac.in
Article Type
Research Article
Date
Received August 01, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025
Abstract
Pseudoexfoliation syndrome (PEX) is a common age-related ocular disorder with systemic inflammatory implications. This cross-sectional study investigated the role of hematological indices-NLR, PLR, dNLR, RDW, SII, SIRI and PIV-in 195 PEX patients and 195 controls. All markers, including novel indices like SII and SIRI, were significantly elevated in PEX (p < 0.05). RDW was also higher, indicating oxidative stress and systemic involvement. These indices may serve as accessible, cost-effective predictors of PEX-related inflammation.
Keywords
Pseudoexfoliation syndrome, inflammation, Neutrophil -Lymphocyte Ratio (NLR), systemic immune-Inflammation index (SII), systemic markers, Red Cell width distribution (RDW)
Citation
Harshitha & Chaitra, Bioinformation 21(8): 2405-2409 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
