Title
Thyroid dysfunction in non-alcoholic fatty liver disease: A case-control study
Authors
Harshit Malkan1, Bhavita Patel2,*, Mahesh G Solu1, Tejas D. Patel3 & Mahammed Kaif Mubrakhusen Bhaniya4
Affiliation
1Department of General Medicine, Dr. Kiran C Patel Medical College and Research Institute, Bharuch, Gujarat, India; 2Department of Biochemistry, Dr. Kiran C Patel Medical College and Research institute, Bharuch, Gujarat, India; 3Department of Orthopaedic Surgery, Dr. Kiran C Patel Medical College & Research Institute, Bharuch, Gujarat, India; 4Trauma Centre, Dr Kiran C Patel Medical College and Research institute, Bharuch, Gujarat, India; *Corresponding author
Harshit Malkan - E-mail: hm1912003@yahoo.com
Bhavita Patel - E-mail: dr.abc2306@gmail.com; Phone: +91 9099812755
Mahesh G Solu - E-mail: drmaheshgsolu@gmail.com
Tejas D. Patel - E-mail: docpateltejas@gmail.com
Mahammed Kaif Mubrakhusen Bhaniya - E-mail: mbhaniya00@gmail.com
Article Type
Research Article
Date
Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025
Abstract
Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a hepatic manifestation of metabolic dysfunction, with emerging evidence linking it to thyroid abnormalities. In this case-control study of 120 adults, thyroid dysfunction was more prevalent in NAFLD cases, with 20% having overt hypothyroidism and 5% subclinical hypothyroidism. Thyroid dysfunction increased with NAFLD severity, with overt hypothyroidism observed in 66.7% of Grade 3 cases. These findings highlight a strong association between worsening thyroid function and NAFLD severity, suggesting the need for routine thyroid screening in NAFLD management.
Keywords
Metabolic dysfunction, non-alcoholic fatty liver disease (NAFLD), thyroid dysfunction
Citation
Malkan et al. Bioinformation 21(8): 2453-2458 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
