Title

Evaluation of cardio-protective effects of a Novel SGLT2 inhibitor beyond glycemic control in preclinical models

Authors

Sunil Kumar¹, Ved Prakash^2,*, Renuka Kattimani³, Sangeeta Gupta⁴, Renju Ravi⁵ & Amrit Podder⁶

Affiliation

¹Department of General Surgery, AIIMS Bibinagar, Hyderabad Metropolitan Region, Telangana, India; ²Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India; ³Department of Ophthalmology, ESIC Medical College, Kalaburagi-Karnataka, India; ⁴Department of Physiology, AIIMS Gorakhpur, Uttar Pradesh, India; ⁵Department of Basic Medical Sciences, Faculty of Medicine, Jazan University, Saudi Arabia; ⁶Department of Physiology, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India; *Corresponding author

Email

Sunil Kumar - E-mail: dkdrsunil0@gmail.com
Ved Prakash - E-mail: sonivedgmc@bhu.ac.in
Renuka Kattimani - E-mail: drrenuka.2002@gmail.com
Sangeeta Gupta - E-mail: drsangeeta77.65@rediffmail.com
Renju Ravi - E-mail: rravi@jazanu.edu.sa
Amrit Podder - E-mail: amritpodder0@gmail.com

Article Type

Research Article

Date

Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025

Abstract

The heart-protective effects of a novel SGLT2 inhibitor (NSI) in diabetic cardiomyopathy, beyond blood sugar control is of interest. NSI was compared with dapagliflozin and Terminalia Arjuna (TA) using preclinical models. Data showed that NSI significantly reduced cardiac injury markers, improved cardiac function and exhibited strong antioxidant properties, outperforming dapagliflozin and matching TA in efficacy. NSI also restored left ventricular ejection fraction and reduced myocardial fibrosis. Thus, we show that NSI may be a promising multifunctional treatment for cardiovascular issues in diabetes.

Keywords

SGLT2 inhibitor, diabetic cardiomyopathy, Terminalia Arjuna, oxidative stress, cardiac biomarkers, cardioprotection

Citation

Kumar et al. Bioinformation 21(8): 2459-2463 (2025)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.