Title

Growth factors and osseointegration in dental implants - A review

Authors

Neelam Chandwani¹*, Preeti Nigotia², Sandeep Kumar Jain³, Nilesh Joshi⁴, Mridula Joshi⁵ & Rashmi Laddha⁶

Affiliation

¹Department of Dentistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India; ²Department of Medicine, SRVS Medical College, Shivpuri, Madhya Pradesh, India; ³Department of Medicine, Chhindwara Institute of Medical Sciences, Madhya Pradesh, India; ⁴Department of Periodontology, Bharati Vidyapeeth (Deemed to be University) Dental College, Navi Mumbai, India; ⁵Department of Prosthodontics, Bharati Vidyapeeth (Deemed to be University) Dental College, Navi Mumbai, India; ⁶Department of Periodontology, Dr. RR Kambe Dental College and Hospital, Akola, Maharashtra, India; *Corresponding author

Email

Neelam Chandwani - E-mail: Drneelamch@gmail.com
Preeti Nigotia - E-mail: preeti9560@gmail.com
Sandeep Kumar Jain - E-mail: drsandeepjain000007@gmail.com
Nilesh Joshi - E-mail: nilesh.joshi@bharatividyapeeth.edu
Mridula Joshi - E-mail: mridula.joshi@bharatividyapeeth.edu
Rashmi Laddha - E-mail: drrashmirdaga@gmail.com

Article Type

Review

Date

Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025

Abstract

Osseointegration is essential for the long-term success of dental implants. However, achieving consistent and rapid integration remains challenging. Growth factors like PDGF, BMPs, TGF-β, IGF, VEGF, PRP and PRF have shown potential to enhance bone healing and implant stability. These agents promote osteoblast activity, angiogenesis and matrix formation, accelerating peri-implant bone regeneration. Delivery methods such as platelet concentrates, surface coatings and biomaterial integration have demonstrated promising outcomes. Therefore, it is of interest to review summarizing the biological rationale, clinical evidence, application techniques and future prospects of growth factor use in implant dentistry.

Keywords

Growth factors, osseointegration, dental implants, bone regeneration, platelet-rich fibrin (PRF), bone morphogenetic proteins (BMP)

Citation

Chandwani et al. Bioinformation 21(8): 2464-2468 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.