Title

Association of gut microbiota dysbiosis with non-alcoholic fatty liver disease: A cross-sectional study

Authors

Lalan Pratap Singh¹, Ruchi Agrawal², Preeti Nigotia³ & Ramesh Agrawal⁴*

Affiliation

¹Department of General Medicine, Government Medical College, Satna, Madhya Pradesh, India; ²Department of Microbiology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India; ³Department of General Medicine, SRVS Medical College, Shivpuri, Madhya Pradesh, India; ⁴Department of Microbiology, Government Medical College, Santa, Madhya Pradesh, India; *Corresponding author

Email

Lalan Pratap Singh - E-mail: lalanmgm1986@gmail.com
Ruchi Agrawal - E-mail: drruchisagrawal@gmail.com
Preeti Nigotia - E-mail: preeti9560@gmail.com
Ramesh Agrawal - E-mail: drrameshagrawal22@gmail.com

Article Type

Research Article

Date

Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025

Abstract

The association between gut microbiota dysbiosis and non-alcoholic fatty liver disease (NAFLD) in 132 adults were diagnosed using ultrasonography. Stool samples were analyzed using 16S rRNA sequencing to assess microbiota composition. Patients with NAFLD showed a significant decrease in Bacteroidetes and an increase in Firmicutes and Proteobacteria compared to controls. Altered microbial diversity correlated with elevated liver enzymes and insulin resistance markers. Data shows that gut microbiota imbalance plays a contributory role in the pathogenesis of NAFLD.

Keywords

NAFLD, gut microbiota, dysbiosis, liver disease, microbial diversity

Citation

Singh et al. Bioinformation 21(8): 2477-2480 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.