Title

Alveolar-derived autologous blood clot as a scaffold for regenerative endodontic treatment: An observational study

Authors

P.B. Gopikrishnan¹, Rajeswari Putchala², Vankala Gautam², Aparna Srivastava³, Rahul Tiwari⁴, Heena Dixit⁵* & Deepak Sharma⁵

Affiliation

¹Department of Conservative and Endodontics, AL -AZHAR DENTAL COLLEGE, Thodupuzha, Kerala, India; ²Department of Conservative & Endodontics, ST. Joseph's Dental College, Duggirala, NTR University of health sciences, Andhra Pradesh, India; ³Department of Conservative Dentistry and Endodontics, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India; ⁴Department of Oral and Maxillofacial Surgery, RKDF Dental College and Research Centre, Sarvepalli Radhakrishnan University, Bhopal, Madhya Pradesh, India, India; ⁵Department of Hospital Administration, Index Institute of Management, Arts and Science, Malwanchal University, Index City, Nemawar Road, Indore, Madhya Pradesh, India; *Corresponding author

Email

P.B. Gopikrishnan - E-mail: drgopimadhav@gmail.com
Rajeswari Putchala - E-mail: dr.rajijoy@gmail.com
Vankala Gautam - E-mail: vankala.gautam@gmail.com
Aparna Srivastava - E-mail: aparnasri1993@gmail.com
Rahul Tiwari - E-mail: drrahulvctiwari@gmail.com
Heena Dixit - E-mail: drheenatiwari@gmail.com
Deepak Sharma - E-mail: deepaksharma@yahoo.com

Article Type

Research Article

Date

Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025

Abstract

Regenerative endodontic treatment (RET) has transformed the management of immature necrotic permanent teeth by promoting biological healing and root development. Hence, a total of 20 patients aged 8-16 years with necrotic immature anterior teeth were enrolled. Blood was collected from a fresh alveolar socket and introduced into the canal space following canal disinfection with triple antibiotic paste. 83.3% showed complete periapical healing, while 72.2% exhibited apical closure and root lengthening by 12 months. We further found that clinical signs such as pain, swelling and sinus tract were resolved in all cases.

Keywords

Regenerative endodontics, blood clot scaffold, immature teeth, apical closure, root development

Citation

Gopikrishnan et al. Bioinformation 21(8): 2486-2489 (2025)

Edited by

Akshaya Ojha

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.