Title
Assessing the diagnostic capability of the macular ganglion cell complex and retinal fiber layer thickness in glaucoma patients
Authors
Tripti Thakur, Nishita Yadav, Nazia Imam & M.S. Ali*
Affiliation
Department of Regional Institute of Ophthalmology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India; *Corresponding author
Tripti Thakur - E-mail: tripti.thakur140188@gmail.com
Nishita Yadav - E-mail: nshtyadav4@gma.com
Nazia Imam - E-mail: naziaimam1234@gmail.com
M.S. Ali - E-mail: mobashirpmch@gmail.com
Article Type
Research Article
Date
Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025
Abstract
The diagnostic value of macular ganglion cell complex (GCC) and retinal nerve fibre layer (RNFL) thickness in glaucoma is of interest. Using OCT imaging, 90 subjects (45 glaucoma and 45 controls) were studied and the thickness of RNFL and GCC was evaluated. The RNFL was significantly lower in glaucoma patients (71.3 ± 6.5 μm) compared to controls (95.2 ± 5.9 μm, p< 0.001) and so was GCC thickness (72.1 ± 7.3 μm versus 90.6 ± 6.8 μm in controls, p< 0.001). The diagnostic accuracy of RNFL (AUC 0.89) was a bit higher than GCC (AUC 0.87). Combined evaluation enhanced the sensitivity of early glaucoma detection, as well as specificity.
Keywords
Glaucoma, optical coherence tomography, ganglion cell complex, retinal nerve fiber layer, diagnostic accuracy, structural biomarkers
Citation
Thakur et al. Bioinformation 21(8): 2570-2573 (2025)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
