Title

Evaluating clonidine and buprenorphine as adjuvants to intrathecal 0.5% hyperbaric bupivacaine in lower limb surgeries

Authors

Sushma Singh¹, V Sushma Naidu² & Gautam Chandra Koshi^3,*

Affiliation

¹Department of Anaesthesia, Government Medical College, Korba, Chhattisgarh, India; ²Department of Pharmacology, PES University Institute of Medical Sciences and Research, Bangalore, Karnataka, India; ³Department of Anaesthesiology, Gandhi Medical College, Bhopal, Madhya Pradesh, India; *Corresponding author

Email

Sushma Singh - E-mail: sush1989.ss@gmail.com

V Sushma Naidu - E-mail: drsushmanaidu@gmail.com
Gautam Chandra Koshi - E-mail: chandrakoshikmusic@gmail.com

Article Type

Research Article

Date

Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025

Abstract

Intrathecal clonidine and buprenorphine as adjuvants to 0.5 percent hyperbaric bupivacaine in lower limb surgery is of interest. Patients were randomly allocated to three control groups, each comprising 30 individuals. The analgesic duration was greatest in Group Bu (buprenorphine 280 +/- 20 min) compared to Group C (clonidine 250 +/- 25 min) and Group B (control 180 +/- 22 min). The clonidine group had increased sedation. Buprenorphine showed reduced damage and minor adverse effects.

Keywords

Clonidine, buprenorphine, intrathecal, bupivacaine, lower limb surgery

Citation

Singh et al. Bioinformation 21(8): 2595-2598 (2025)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.