Title

Effects of intravenous lignocaine, dexamethasone and their combination on propofol-induced pain

Authors

Pragyashri Baghel¹, Ikraz Patel², Anushree Shukla³ & Gopal Eekwale^4,*

Affiliation

¹Department of Anaesthesia, NSCB Medical College, Jabalpur, Madhya Pradesh, India; ²Department of Medicine, SAIMS Medical College, Indore, Madhya Pradesh, India; ³Department of Anesthesia, Apollo Hospitals, Indore, Madhya Pradesh, India; ⁴Department of Anaesthesiology, M.G.M. Medical College & MY Hospital, Indore, Madhya Pradesh, India; *Corresponding author

Email

Pragyashri Baghel - E-mail: pragyashri.baghel@gmail.com

Ikraz Patel - E-mail: ikrazpatel4444@gmail.com

Anushree Shukla - E-mail: shukla.anu1993@gmail.com

Gopal Eekwale - E-mail: gopal.ekwale@gmail.com

Article Type

Research Article

Date

Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025

Abstract

Injection of propofol may provoke pain in up to 70 percent of the patients. In this randomized, double-blind study, the effects of lignocaine, dexamethasone and a combination of both on propofol-induced pain were evaluated in 90 surgical patients. The highest incidence of pain found was in the lignocaine group (70%) and the lowest in the combination group (30%). The combined pretreatment also showed significantly reduced mean pain scores (p < 0.01). The combination of lignocaine-dexamethasone was best effective and this might be embraced in reducing propofol-induced pain.

Keywords

Propofol-induced pain, lignocaine, dexamethasone, intravenous anesthesia, pain management, pre-treatment agents

Citation

Baghel et al. Bioinformation 21(8): 2603-2607 (2025)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.