Title

Lugol's iodine-guided excision margin determination in oral mucosal lesion management

Authors

Ranjeeta Yumnam^1,*, Shruthi Rangaswamy², Deepak Ningombam Singh³, Jenny Atom⁴, Ahanthem Nandita³ & Sachidananda Chungkham⁵

Affiliation

¹Department of Oral & Maxillofacial Surgery, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India; ²Department of Oral & Maxillofacial Surgery, Rajarajeshwari Dental College, Bangalore, Karnataka, India; ³Department of Oral Medicine and Radiology, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India; ⁴Department of Conservative Dentistry & Endodontics, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India; ⁵Department of Periodontics, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India; *Corresponding author

Email

Ranjeeta Yumnam - E-mail: drranjeetay@gmail.com
Shruthi Rangaswamy - E-mail: shruthiphd1@gmail.com
Deepak Ningombam Singh - E-mail: deepakningombam1@gmail.com
Jenny Atom - E-mail: jennyatom304@gmail.com
Ahanthem Nandita - E-mail: dr.a.nandita24@gmail.com
Sachidananda Chungkham - E-mail: sachidananda.ch@gmail.com

Article Type

Research Article

Date

Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025

Abstract

Lugol's iodine (LI) is recognized for its diagnostic efficacy in identifying and delineating sufficient margins of the biopsy region. Therefore, it is of interest to evaluate the variance in excision margins between visual assessment and LI as well as to histopathologically analyze the disease-free margin post-excision. The diameters of the lesions were statistically compared before and after the application of LI in 18 male patients. The histopathological report was assessed for disease-free margins. Data shows that LI stain is an essential method for assessing the progression/excision margins of suspicious oral lesions, hence aiding in the early identification of oral cancer.

Keywords

Diagnostic efficiency, dysplasia, excision margins, lugol’s iodine, oral mucosal lesions

Citation

Yumnam et al. Bioinformation 21(8): 2631-2634 (2025)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.