Assessment of biodentine, mineral trioxide aggregate and enamel matrix derivative as direct pulp-capping agents

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Title	Assessment of biodentine, mineral trioxide aggregate and enamel matrix derivative as direct pulp-capping agents
Authors	Shivali Vaid¹, Ankitha Ade², Abhishek Mishra³, Bonny Paul⁴, Kavita Dube⁴, Rishav Singh⁵, Sanapala Mounika⁶ &Megha Ghosh^7,*
Affiliation	¹Department of Oral Maxillofacial Pathology & Microbiology, MaharanaPratap College of Dentistry & Research Centre, Gwalior, Madhya Pradesh, India; ²Department of Conservative Dentistry and Endodontics, Elite Dental Clinic and Maxillofacial Center, Ongole, India; ³Department of Oral & Maxillofacial Surgery, ITS Dental College, Greater Noida, India; ⁴Department of Conservative Dentistry and Endodontics, Hitkarini Dental College, Jabalpur, Madhya Pradesh, India; ⁵Department of Pedodontics & Preventive Dentistry, Maharaja Ganga Singh Dental College & Research Centre, Sri Ganganagar, Rajasthan, India; ⁶Intern, Kalinga Institute of Dental Science, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Patia, Bhubaneswar, Odisha, India; ⁷Department of Conservative Dentistry and Endodontics, College of Dental Sciences and Hospital, Rau, Indore, Madhya Pradesh, Indore, India; *Corresponding author
Email	Shivali Vaida - E-mail: sgivalivaid@gmail.com Ankitha Ade - E-mail: ankitha1014@gmail.com Abhishek Mishra - E- mail: dr_abhishek_mishra@yahoo.com Bonny Paul - E-mail: bonnypaul40@gmail.com Kavita Dube - E-mail: drkdube@gmail.com Rishav Singh - E-mail: drrishavsingh@hotmail.com Sanapala Mounika - E-mail: smounika900@gmail.com Megha Ghosh - E-mail: ghoshmegha28@gmail.com
Article Type	Research Article
Date	Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025
Abstract	Conservative pulp treatments are used to maintain the tooth's vitality. Therefore, it is of interest to assess the clinical, radiographic and histologic responses of the pulp-dentin complex after direct capping with the MTA, Biodentine and Enamel Matrix Derivative (EMD) in human permanent teeth. A sterile rotary round bur was used to mechanically expose the pulps of 36 premolars that were advised for extraction. The teeth were then divided to one of three experimental groups: MTA, Biodentine and Enamel Matrix Derivative (EMD). The creation of the dentine bridge was evaluated using radiographs and histology. Clinically absence of signs symptoms was noted. MTA had the highest dentine bridge formation, followed by biodentine and EMD.
Keywords	Biodentine, direct pulp capping, enamel matrix derivative (EMD), histology, MTA, pulpal reaction
Citation	Vaid et al. Bioinformation 21(8): 2675-2679 (2025)
Edited by	P Babaji
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.