Title
Effect of leukoreduction in preventing febrile transfusion reactions
Authors
Keshav R Kulkarni*
Affiliation
Department of Pathology, S. Nijalingappa Medical College & H.S.K. Hospital & Research Centre, Nava Nagar, Bagalkote, Karnataka, India; *Corresponding author
Keshav R Kulkarni - E-mail: keshavkulkarni1008@gmail.com
Article Type
Research Article
Date
Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025
Abstract
Febrile non-hemolytic transfusion reactions (FNHTRs) remain one of the most common adverse events associated with packed red blood cell (PRBC) transfusions. Therefore, it is of interest to compare the efficacy of leukoreduction in the prevention of febrile transfusion reactions in PRBC-transfused patients using the TACE 2 automatic component extractor and Terumo Penpol blood bags. 600 PRBC transfusions were included in the analysis, of which 300 were leukoreduced and 300 were not leukoreduced. The standard operating procedures for leukoreduction were adopted with the help of the TACE 2 device and the rate of FNHTRs was noted and compared between the two groups. Leukoreduction greatly minimized the occurrence of febrile non-hemolytic transfusion reactions. Its application with automated extraction systems such as TACE 2 and quality blood bags like those of Terumo Penpol provided safe, effective and repeatable results.
Keywords
Leukoreduction, ionfebrile non-hemolytic transfusion reactions, PRBC, TACE 2 extractor, terumo penpol, blood safety, automated blood component separator
Citation
Kulkarni, Bioinformation 21(8): 2772-2775 (2025)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
