Title

Correlation of serum cytokine levels with disease severity in psoriasis: A physiological insight into inflammatory markers

Authors

Raghav Gupta¹, Devpriya Shukla², Amit Saxena² & Sanjay Prasad^3,*

Affiliation

¹Department of Dermatology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India; ²Department of General Medicine, Bundelkhand Medical College, Sagar, Madhya Pradesh, India; ³Department of Psychiatry, Bundelkhand Medical College, Sagar, Madhya Pradesh, India; *Corresponding author

Email

Raghav Gupta - E-mail: rockingraghav04@gmail.com
Devpriya Shukla - E-mail: devpriyashukla27@gmail.com
Amit Saxena - E-mail: drsaxenaamit04@gmail.com
Sanjay Prasad - E-mail: sp3289@gmail.com

Article Type

Research Article

Date

Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025

Abstract

Psoriasis is a chronic immune-mediated skin disorder in which systemic inflammation and cytokine dysregulation play central roles. Identifying correlations between cytokine levels and disease severity may aid in establishing reliable biomarkers. In this cross-sectional study, 60 psoriasis patients and 30 healthy controls were evaluated; PASI scores were recorded and serum TNF-α, IL-6 and IL-17 levels was measured using ELISA. All three cytokines were significantly elevated in patients and showed strong positive correlations with PASI scores. Elevated TNF-α, IL-6 and IL-17 may serve as biomarkers of disease activity and potential therapeutic targets in psoriasis management.

Keywords

Psoriasis, cytokines, inflammation, TNF-α, IL-6, IL-17, PASI score, biomarkers, disease severity.

Citation

Gupta et al. Bioinformation 21(8): 2803-2806 (2025)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.