Title
Oral side effects of dermatologic therapies: A systematic review and meta-analysis
Authors
Reem M. Alqahtani1, Ahmad F. Alsarrah1, Saud M. Almutiari1, A Althuwayb Fajr Ehab1, F. Alanazi Abdulmohsen Abdulkarim1, Abdalwhab Zwiri1, Mohammed Ghazi Sghaireen3,* & Mohammad Khursheed Alam4,5,6*
Affiliation
1Department of Dermatology, College of Medicine, Jouf University, Sakaka, Saudi Arabia; 2Department of Dentistry, Applied Sciences Private University, Amman, Al-Arab Street, 21. Jordan; 3Department of Prosthetic Dentistry, College of Dentistry, Jouf University, Sakaka, Kingdom of Saudi Arabia; 4Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka, Saudi Arabia; 5Department of Dental Research Cell, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Chennai, India; 6Department of Public Health, Daffodil International University, Dhaka 1207, Bangladesh, India; *Corresponding author
Reem M. Alqahtani - E-mail: drreemalqhtani216@gmail.com
Ahmad F. Alsarrah - E-mail: Ahmadfsalsarrah@gmail.com
Saud M. Almutiari - E-mail: saudalmitiri@gmail.com
A. Althuwayb Fajr Ehab - E-mail: Fajrehab2004@gmail.com
F. Alanazi Abdulmohsen Abdulkarim - E-mail: fajrehab2004@gmail.com
Abdalwhab Zwiri - E-mail: a_zwiri@asu.edu.jo
Mohammed Ghazi Sghaireen - E-mail: dr.mohammed.sghaireen@jodent.org
Mohammad Khursheed Alam - E-mail: mkalam@ju.edu.sa
Article Type
Review
Date
Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025
Abstract
Dermatologic treatments can produce clinically significant oral side effects that remain poorly quantified. A significant association between dermatologic therapies and oral complications (ES=1.55, 95% CI: 0.94–2.17, p<0.001) is observed, despite high heterogeneity (I²=96%). Retinoids were predominantly associated with cheilitis and xerostomia, immunosuppressants with mucositis and ulcerations, and JAK inhibitors with opportunistic infections. Thus, data shows the necessity of routine oral assessments and preventive strategies to reduce therapy-related morbidity.
Keywords
Dermatologic agents; oral manifestations; drug-related side effects; adverse reactions; systematic review; meta-analysis
Citation
Alqahtani et al. Bioinformation 21(8): 2833-2840 (2025)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
