Title
Association of vitamin D deficiency with insulin resistance among type 2 diabetes mellitus patients - A case-control study
Authors
Pankaj Kumar Jain1, Preeti Nigotia2, Arun Mishra3 & Lalan Pratap Singh4,*
Affiliation
1Department of General Medicine, NSC Government Medical College, Khandwa, Madhya Pradesh, India; 2Department of General Medicine, SRVS Medical College, Shivpuri, Madhya Pradesh, India; 3Department of Biochemistry, NSC Government Medical College Khandwa, Madhya Pradesh, India; 4Department of General Medicine, Government Medical College, Satna, Madhya Pradesh, India; *Corresponding author
Pankaj Kumar - E-mail: drpankajjain07@gmail.com
Preeti Nigotia - E-mail: preeti9560@gmail.com
Arun Mishra - E-mail: mishra.arun907@gmail.com
Lalan Pratap Singh - E-mail: lalanmgm1986@gmail.com
Article Type
Research Article
Date
Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025
Abstract
The association between vitamin D deficiency and insulin resistance is of interest. Hence, 140 participants-70 type 2 diabetes mellitus (T2DM) patients and 70 age- and sex-matched healthy controls were evaluated. Serum 25(OH) vitamin D levels and HOMA-IR scores were measured and compared. Vitamin D levels were significantly lower and HOMA-IR significantly higher in T2DM patients compared to controls. An inverse correlation was observed between vitamin D levels and insulin resistance. Thus, we show a potential role of vitamin D deficiency in the pathophysiology of insulin resistance in T2DM.
Keywords
Vitamin D deficiency, type 2 diabetes mellitus, insulin resistance, HOMA-IR, case-control study
Citation
Jain et al. Bioinformation 21(8): 2897-2900 (2025)
Edited by
A Prashanth
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
