Title
Virulence between ESBL and non-ESBL producing isolates of Acinetobacter baumanii causing diabetic foot infections
Authors
Hirdesh Kumari Gupta1,*, Ramanath Karicheri1 & Abhishek Mehta2
Affiliation
1Department of Microbiology, Index Medical College and Research Centre, Nemawar, Indore, Madhya Pradesh, India; 2Department of Microbiology, Government Medical College Datia, Madhya Pradesh, India; *Corresponding author
Hirdesh Kumari Gupta - E-mail: hirdeshguptamicro2018@gmail.com; Phone: +91 6394377583
Ramanath Karicheri - E-mail: ramnath.karicheri@gmail.com; Phone: +91
9538787497
Abhishek Mehta - E-mail: abhishekmehta623@gmail.com; Phone: +91
8077538542
Article Type
Research Article
Date
Received August 1, 2025; Revised August 31, 2025; Accepted August 31, 2025, Published August 31, 2025
Abstract
Acinetobacter baumannii is an opportunistic pathogen associated commonly with healthcare-associated-infections and predominantly involved in diabetic foot infections with virulence factors determining pathogenicity especially in multidrug resistant strains. Therefore, it is of interest to compare virulence factors (pellicle formation and gelatinase activity) between Extended-spectrum beta-lactamase (ESBL) and non-ESBL producing Acinetobacter baumannii isolates derived from diabetic foot ulcer infection (DFI). The isolates were identified using standard microbiological methods and antimicrobial susceptibility test was done by Kirby Bauer disk diffusion method. The double disk synergy test method (DDST) was used to detect ESBL production. The formation of pellicle at 37°C and gelatinase production indicated high virulence in ESBL producers. Colistin and polymyxin B were found to be the only options effective against multidrug-resistant Acinetobacter baumannii infections.
Keywords
Acinetobacter baumannii, diabetic foot ulcer, gelatinase, multidrug resistance, pellicle formation
Citation
Gupta et al. Bioinformation 21(8): 2942-2945 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
