Title

Linking thyroid dysfunction with chronic kidney disease among Indian patients

Authors

Gayathri Chelamkuri¹, Nalugotla Lakshmanna^1,*, Vadlamudi Chandramohan² & Veluri Ganesh³

Affiliation

¹Department of Biochemistry, Kurnool Medical College, Kurnool, Andhra Pradesh, India; ²Department of Biochemistry, Government Medical College, Paderu, Andhra Pradesh, India; ³Department of Biochemistry, PES University Institute of Medical Sciences and Research, Electronic City, Bengaluru, Karnataka, India; *Corresponding author

Email

Gayathri Chelamkuri - E-mail: gayathrichelamkuri@gmail.com
Nalugotla Lakshmanna - E-mail: laxman77975@gmail.com

Vadlamudi Chandramohan - E-mail: cmvadlamudi@gmail.com
Veluri Ganesh - E-mail: ganeshbabu370@yahoo.com

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

The implications of chronic kidney disease are extensive and affect the pituitary-thyroid axis and peripheral metabolism of thyroid hormones causing significant thyroid dysfunction. The present cross-sectional study includes 90 chronic kidney disease diagnosed patients. We investigated for blood parameters like urea, creatinine and thyroid biomarkers. The overall prevalence of thyroid abnormalities in the study group was 65.56%, 59 out of 90 subjects were observed to have derangements in thyroid biomarkers. The Pearson's correlation reveled there was a significant negative correlation between the serum thyroid stimulating hormone levels and the estimated glomerular filtration (r=-0.04, P=0.001**). This study emphasizes the thyroid derangements of clinical relevance in chronic kidney disease patients which may be helpful to clinicians for better patient care.

Keywords

Chronic kidney disease, hypothyroidism and estimated GFR (eGFR)

Citation

Chelamkuri et al. Bioinformation 21(9): 2966-2970 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.