Title

Correlation of serum adiponectin with thyroid profile among metabolic syndrome patients with and without hypothyroidism

Authors

D. Selvakumar¹, A. Pavana^2,*, Nalugotla Lakshmanna³, Gnanadesigan Ekambaram⁴ & Veluri Ganesh⁵

Affiliation

¹Department of Biochemistry, PES Institute of Medical Sciences and Research, Kuppam, Chittoor, Andhra Pradesh, India; ²Department of Biochemistry, Sri Siddhartha Institute Of Medical Sciences, T Begur, Karnataka, India; ³Department of Biochemistry, Kurnool Medical College, Kurnool Andhra Pradesh, India; ⁴Department of Physiology, Nootan Medical College and Research Centre, Sankalchand Patel University, Visnagar, Gujarat, India; ⁵Department of Biochemistry, PES University Institute of Medical Sciences and Research, Electronic City, Bengaluru, Karnataka, India; *Corresponding author

Email

D. Selvakumar - E-mail: selvarajmscbio@gmail.com
A. Pavana - E-mail: drpavanaabiochemssimsrc@gmail.com
Nalugotla Lakshmanna - E-mail: laxman77975@gmail.com
Gnanadesigan Ekambaram - E-mail: edesigan_phy@nootanmedical.edu.in
Veluri Ganesh - E-mail: ganeshbabu370@yahoo.com

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

The Metabolic Syndrome is becoming a more significant global public health condition, and look for reliable, sensitive biomarkers that may be used as diagnostic tools to identify metabolic syndrome. Therefore, it is of interest to correlate the serum adiponectin with thyroid profile in metabolic syndrome patients with and without hypothyroidism. This is a cross-sectional study that included total 120 metabolic syndromes with and without hypothyroidism and 30 healthy controls. The analysis of biochemical and experimental parameters was done. The serum adiponectin was significant and drastically decreased levels was observed in metabolic syndrome patients with and without hypothyroidism and healthy controls (P = 0.001**). It was observed that serum adiponectin was negatively correlated with blood sugars, lipid profile, MDA, TSH and positively correlated with FRAP (P = 0.001**). Thus, we show significantly decreased levels of serum adiponectin among metabolic syndrome patients with and without hypothyroidism might be useful for identify complications like type 2 diabetes mellitus and cardiovascular diseases.

Keywords

Adiponectin, ferric reducing ability of plasma, malondialdehyde, metabolic syndrome

Citation

Selvakumar et al. Bioinformation 21(9): 2971-2976 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.