Title

Assessment of nerve regeneration using nerve guidance conduits in inferior alveolar nerve injuries

Authors

Ankita Shrivastava¹, Manoj Manohar², Kanishka Guru¹*, Mony Behera³, Yeso Alekhya⁴ & Sameer Gupta⁵

Affiliation

¹Department of Dentistry, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India; ²Department of Oral and Maxillofacial Surgeon, Corona Dental Care, Vidyaranyapura, Bangalore, India; ³Kalinga Institute of Dental Sciences (KIDS), Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, Odisha, India; ⁴Department of Oral Medicine and Radiology, Meghna Institute of Dental Sciences, Nizamabad, Telangana; ⁵Department of Oral & Maxillofacial Surgery, Inderprastha Dental College and Hospital, Sahibabad, Ghaziabad, Uttar Pradesh, India; *Corresponding author

Email

Ankita Shrivastava - E-mail: dr.ankita2909@gmail.com
Manoj Manohar - E-mail: drmanojmanohar@gmail.com
Kanishka Guru - E-mail: kanishkanavinguru@gmail.com
Mony Behera - E-mail: monybehera99@gmail.com
Yeso Alekhya - E-mail: sona.alekhya.026@gmail.com
Sameer Gupta - E-mail: sameer.gupta83@yahoo.in

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

Injuries to the inferior alveolar nerve (IAN) often cause persistent sensory deficits and current treatment options such as autografts have limitations. Therefore, it is of interest to evaluate the role of collagen-based nerve guidance conduits (NGCs) in promoting IAN regeneration in 20 rabbits with 5 mm nerve gaps. Functional recovery was assessed by whisker movement scores, electrophysiology and histomorphometric analysis at 4, 8 and 12 weeks. Results showed significantly better outcomes in the NGC group, including higher whisker movement scores, improved CMAP amplitudes and greater axon counts compared to controls. Thus, we show that NGCs enhance structural and functional nerve recovery and represent a promising therapeutic approach for peripheral nerve repair in the maxillofacial region.

Keywords

Shrivastava et al. Bioinformation 21(9): 2988-2991 (2025)

Citation

Inferior alveolar nerve, nerve regeneration, nerve guidance conduit, peripheral nerve injury, histomorphometry, rabbit model

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.